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2b63

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[[Image:2b63.gif|left|200px]]
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{{STRUCTURE_2b63| PDB=2b63 | SCENE= }}
{{STRUCTURE_2b63| PDB=2b63 | SCENE= }}
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'''Complete RNA Polymerase II-RNA inhibitor complex'''
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===Complete RNA Polymerase II-RNA inhibitor complex===
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==Overview==
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The noncoding RNA B2 and the RNA aptamer FC bind RNA polymerase (Pol) II and inhibit messenger RNA transcription initiation, but not elongation. We report the crystal structure of FC(*), the central part of FC RNA, bound to Pol II. FC(*) RNA forms a double stem-loop structure in the Pol II active center cleft. B2 RNA may bind similarly, as it competes with FC(*) RNA for Pol II interaction. Both RNA inhibitors apparently prevent the downstream DNA duplex and the template single strand from entering the cleft after DNA melting and thus interfere with open-complex formation. Elongation is not inhibited, as nucleic acids prebound in the cleft would exclude the RNA inhibitors. The structure also indicates that A-form RNA could interact with Pol II similarly to a B-form DNA promoter, as suggested for the bacterial transcription inhibitor 6S RNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 16341226 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16341226}}
==About this Structure==
==About this Structure==
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[[Category: Rna]]
[[Category: Rna]]
[[Category: Rna polymerase ii]]
[[Category: Rna polymerase ii]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:54:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:56:04 2008''

Revision as of 21:56, 28 July 2008

Image:2b63.png

Template:STRUCTURE 2b63

Complete RNA Polymerase II-RNA inhibitor complex

Template:ABSTRACT PUBMED 16341226

About this Structure

2B63 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs., Kettenberger H, Eisenfuhr A, Brueckner F, Theis M, Famulok M, Cramer P, Nat Struct Mol Biol. 2006 Jan;13(1):44-8. Epub 2005 Dec 11. PMID:16341226

Page seeded by OCA on Tue Jul 29 00:56:04 2008

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