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2p6u

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{{STRUCTURE_2p6u| PDB=2p6u | SCENE= }}
{{STRUCTURE_2p6u| PDB=2p6u | SCENE= }}
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'''Apo structure of the Hel308 superfamily 2 helicase'''
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===Apo structure of the Hel308 superfamily 2 helicase===
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==Overview==
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To reveal the mechanism of processive strand separation by superfamily-2 (SF2) 3'--&gt;5' helicases, we determined apo and DNA-bound crystal structures of archaeal Hel308, a helicase that unwinds lagging strands and is related to human DNA polymerase theta. Our structure captures the duplex-unwinding reaction, shows that initial strand separation does not require ATP and identifies a prominent beta-hairpin loop as the unwinding element. Similar loops in hepatitis C virus NS3 helicase and RNA-decay factors support the idea that this duplex-unwinding mechanism is applicable to a broad subset of SF2 helicases. Comparison with ATP-bound SF2 enzymes suggests that ATP promotes processive unwinding of 1 base pair by ratchet-like transport of the 3' product strand. Our results provide a first structural framework for strand separation by processive SF2 3'--&gt;5' helicases and reveal important mechanistic differences from SF1 helicases.
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{{ABSTRACT_PUBMED_17558417}}
==About this Structure==
==About this Structure==
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[[Category: Dna repair]]
[[Category: Dna repair]]
[[Category: Sf2 helicase]]
[[Category: Sf2 helicase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:30:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:38:30 2008''

Revision as of 22:38, 28 July 2008

Image:2p6u.png

Template:STRUCTURE 2p6u

Apo structure of the Hel308 superfamily 2 helicase

Template:ABSTRACT PUBMED 17558417

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural basis for DNA duplex separation by a superfamily-2 helicase., Buttner K, Nehring S, Hopfner KP, Nat Struct Mol Biol. 2007 Jul;14(7):647-52. Epub 2007 Jun 10. PMID:17558417

Page seeded by OCA on Tue Jul 29 01:38:30 2008

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