1wvr

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[[Image:1wvr.gif|left|200px]]
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{{Seed}}
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[[Image:1wvr.png|left|200px]]
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{{STRUCTURE_1wvr| PDB=1wvr | SCENE= }}
{{STRUCTURE_1wvr| PDB=1wvr | SCENE= }}
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'''Crystal Structure of a CRISP family Ca-channel blocker derived from snake venom'''
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===Crystal Structure of a CRISP family Ca-channel blocker derived from snake venom===
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==Overview==
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The cysteine-rich secretory proteins (CRISPs) are widely distributed in mammals, reptiles, amphibians and secernenteas, and are involved in a variety of biological reactions. Here we report the crystal structure of triflin, a snake venom derived blocker of high K(+)-induced artery contraction, at 2.4A resolution. Triflin consists of two domains. The first 163 residues form a large globular body with an alpha-beta-alpha sandwich core, which resembles pathogenesis-related proteins of group-1 (PR-1). Two glutamic acid-associated histidine residues are located in an elongated cleft. A Cd(2+) resides in this binding site, and forms a five-coordination sphere. The subsequent cysteine-rich domain adopts a rod-like shape, which is stabilized by five disulfide bridges. Hydrophobic residues, which may obstruct the target ion-channel, are exposed to the solvent. A concave surface, which is surrounded by these two domains, is also expected to play a significant role in the binding to the target receptor, leading to ion channel blockage. The C-terminal cysteine-rich region has a similar tertiary structure to voltage-gated potassium channel blocker toxins, such as BgK and ShK. These findings will contribute toward understanding the functions of the widely distributed CRISP family proteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_15953617}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15953617 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15953617}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Crystal structure of a CRISP family Ca2+ -channel blocker derived from snake venom., Shikamoto Y, Suto K, Yamazaki Y, Morita T, Mizuno H, J Mol Biol. 2005 Jul 22;350(4):735-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15953617 15953617]
Crystal structure of a CRISP family Ca2+ -channel blocker derived from snake venom., Shikamoto Y, Suto K, Yamazaki Y, Morita T, Mizuno H, J Mol Biol. 2005 Jul 22;350(4):735-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15953617 15953617]
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Cloning and characterization of novel snake venom proteins that block smooth muscle contraction., Yamazaki Y, Koike H, Sugiyama Y, Motoyoshi K, Wada T, Hishinuma S, Mita M, Morita T, Eur J Biochem. 2002 Jun;269(11):2708-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12047379 12047379]
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Wide distribution of cysteine-rich secretory proteins in snake venoms: isolation and cloning of novel snake venom cysteine-rich secretory proteins., Yamazaki Y, Hyodo F, Morita T, Arch Biochem Biophys. 2003 Apr 1;412(1):133-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12646276 12646276]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Trimeresurus flavoviridis]]
[[Category: Trimeresurus flavoviridis]]
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[[Category: Yamazaki, Y.]]
[[Category: Yamazaki, Y.]]
[[Category: Cysteine-rich secretory protein]]
[[Category: Cysteine-rich secretory protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:12:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:38:50 2008''

Revision as of 22:38, 28 July 2008

Image:1wvr.png

Template:STRUCTURE 1wvr

Crystal Structure of a CRISP family Ca-channel blocker derived from snake venom

Template:ABSTRACT PUBMED 15953617

About this Structure

1WVR is a Single protein structure of sequence from Trimeresurus flavoviridis. Full crystallographic information is available from OCA.

Reference

Crystal structure of a CRISP family Ca2+ -channel blocker derived from snake venom., Shikamoto Y, Suto K, Yamazaki Y, Morita T, Mizuno H, J Mol Biol. 2005 Jul 22;350(4):735-43. PMID:15953617

Cloning and characterization of novel snake venom proteins that block smooth muscle contraction., Yamazaki Y, Koike H, Sugiyama Y, Motoyoshi K, Wada T, Hishinuma S, Mita M, Morita T, Eur J Biochem. 2002 Jun;269(11):2708-15. PMID:12047379

Wide distribution of cysteine-rich secretory proteins in snake venoms: isolation and cloning of novel snake venom cysteine-rich secretory proteins., Yamazaki Y, Hyodo F, Morita T, Arch Biochem Biophys. 2003 Apr 1;412(1):133-41. PMID:12646276

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