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2fhy

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[[Image:2fhy.gif|left|200px]]
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{{Seed}}
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[[Image:2fhy.png|left|200px]]
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{{STRUCTURE_2fhy| PDB=2fhy | SCENE= }}
{{STRUCTURE_2fhy| PDB=2fhy | SCENE= }}
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'''Structure of human liver FPBase complexed with a novel benzoxazole as allosteric inhibitor'''
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===Structure of human liver FPBase complexed with a novel benzoxazole as allosteric inhibitor===
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==Overview==
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We have identified benzoxazole benzenesulfonamide 1 as a novel allosteric inhibitor of fructose-1,6-bisphosphatase (FBPase-1). X-ray crystallographic and biological studies of 1 indicate a distinct binding mode that recapitulates features of several previously reported FBPase-1 inhibitor classes.
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The line below this paragraph, {{ABSTRACT_PUBMED_16442285}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16442285 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16442285}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode., von Geldern TW, Lai C, Gum RJ, Daly M, Sun C, Fry EH, Abad-Zapatero C, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1811-5. Epub 2006 Jan 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16442285 16442285]
Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode., von Geldern TW, Lai C, Gum RJ, Daly M, Sun C, Fry EH, Abad-Zapatero C, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1811-5. Epub 2006 Jan 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16442285 16442285]
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Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase., Lai C, Gum RJ, Daly M, Fry EH, Hutchins C, Abad-Zapatero C, von Geldern TW, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1807-10. Epub 2006 Jan 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16446092 16446092]
[[Category: Fructose-bisphosphatase]]
[[Category: Fructose-bisphosphatase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Benzoxazole]]
[[Category: Benzoxazole]]
[[Category: Intersubunit allosteric inhibition of human fpbase]]
[[Category: Intersubunit allosteric inhibition of human fpbase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:55:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:18:50 2008''

Revision as of 23:18, 28 July 2008

Image:2fhy.png

Template:STRUCTURE 2fhy

Structure of human liver FPBase complexed with a novel benzoxazole as allosteric inhibitor

Template:ABSTRACT PUBMED 16442285

About this Structure

2FHY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode., von Geldern TW, Lai C, Gum RJ, Daly M, Sun C, Fry EH, Abad-Zapatero C, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1811-5. Epub 2006 Jan 25. PMID:16442285

Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase., Lai C, Gum RJ, Daly M, Fry EH, Hutchins C, Abad-Zapatero C, von Geldern TW, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1807-10. Epub 2006 Jan 30. PMID:16446092

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