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1qcq

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[[Image:1qcq.gif|left|200px]]
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{{STRUCTURE_1qcq| PDB=1qcq | SCENE= }}
{{STRUCTURE_1qcq| PDB=1qcq | SCENE= }}
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'''UBIQUITIN CONJUGATING ENZYME'''
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===UBIQUITIN CONJUGATING ENZYME===
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==Overview==
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The three-dimensional structure of a yeast ubiquitin-conjugating enzyme, encoded by the Saccharomyces cerevisiae UBC4 gene, has been determined at 2.7 A. The structure was solved using molecular replacement techniques and refined by simulated annealing to an R-factor of 0.198. Bond lengths and angles in the molecule have root mean square deviations from ideal values of 0.018 A and 4.0 degrees, respectively. Ubc4 is an alpha/beta protein with four alpha-helices and a four-stranded antiparallel beta-sheet. The ubiquitin-accepting cysteine is located in a cleft between two loops. Comparison with the recently determined structure of a different plant enzyme suggests that class I ubiquitin-conjugating enzymes are highly conserved in their three-dimensional folding. Except for two extra residues at the N- and the C-terminus of the plant enzyme, the C alpha atoms of the two enzymes can be superimposed with a root mean square deviation of only 1.52 A. Greater variations are found between the surfaces of the two molecules, as most of the identical residues between the two enzymes are either buried or clustered on the surface that lies adjacent to the ubiquitin-accepting cysteine. We suggest that this conserved surface functions in protein-protein binding during ubiquitin thiol ester formation.
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The line below this paragraph, {{ABSTRACT_PUBMED_8268156}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8268156 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8268156}}
==About this Structure==
==About this Structure==
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[[Category: Ubiquitin-conjugating enzyme]]
[[Category: Ubiquitin-conjugating enzyme]]
[[Category: Yeast]]
[[Category: Yeast]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:08:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:51:53 2008''

Revision as of 23:51, 28 July 2008

Image:1qcq.png

Template:STRUCTURE 1qcq

UBIQUITIN CONJUGATING ENZYME

Template:ABSTRACT PUBMED 8268156

About this Structure

1QCQ is a Single protein structure of sequence from Saccharomyces cerevisiae. This structure supersedes the now removed PDB entry 2uce. Full crystallographic information is available from OCA.

Reference

Tertiary structures of class I ubiquitin-conjugating enzymes are highly conserved: crystal structure of yeast Ubc4., Cook WJ, Jeffrey LC, Xu Y, Chau V, Biochemistry. 1993 Dec 21;32(50):13809-17. PMID:8268156

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