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2d2q

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[[Image:2d2q.gif|left|200px]]
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{{STRUCTURE_2d2q| PDB=2d2q | SCENE= }}
{{STRUCTURE_2d2q| PDB=2d2q | SCENE= }}
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'''Crystal structure of the dimerized radixin FERM domain'''
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===Crystal structure of the dimerized radixin FERM domain===
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==Overview==
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ERM (ezrin/radixin/moesin) proteins bind to the cytoplasmic tail of adhesion molecules in the formation of the membrane-associated cytoskeleton. The binding site is located in the FERM (4.1 and ERM) domain, a domain that is masked in the inactive form. A conventional masking motif, strand 1 (residues 494-500 in radixin), has previously been identified in the C-terminal tail domain. Here, the crystal structure of dimerized radixin FERM domains (residues 1-310) is presented in which the binding site of one molecule is occupied by the C-terminal residues (residues 295-304, strand 2) of the other molecule. The residues contain a conserved motif that is compatible with that identified in the adhesion molecules. The residues might serve as a second masking region in the inactive form of ERM proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 16582480 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16582480}}
==About this Structure==
==About this Structure==
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[[Category: Homo dimer]]
[[Category: Homo dimer]]
[[Category: Masking]]
[[Category: Masking]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:35:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:21:02 2008''

Revision as of 00:21, 29 July 2008

Template:STRUCTURE 2d2q

Crystal structure of the dimerized radixin FERM domain

Template:ABSTRACT PUBMED 16582480

About this Structure

2D2Q is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of dimerized radixin FERM domain suggests a novel masking motif in C-terminal residues 295-304., Kitano K, Yusa F, Hakoshima T, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt, 4):340-5. Epub 2006 Mar 25. PMID:16582480

Page seeded by OCA on Tue Jul 29 03:21:02 2008

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