1ow3

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{{STRUCTURE_1ow3| PDB=1ow3 | SCENE= }}
{{STRUCTURE_1ow3| PDB=1ow3 | SCENE= }}
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'''Crystal Structure of RhoA.GDP.MgF3-in Complex with RhoGAP'''
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===Crystal Structure of RhoA.GDP.MgF3-in Complex with RhoGAP===
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==Overview==
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The formation of complexes between small G proteins and certain of their effectors can be facilitated by aluminum fluorides. Solution studies suggest that magnesium may be able to replace aluminum in such complexes. We have determined the crystal structure of RhoA.GDP bound to RhoGAP in the presence of Mg(2+) and F(-) but without Al(3+). The metallofluoride adopts a trigonal planar arrangement instead of the square planar structure of AlF(4)(-). We have confirmed that these crystals contain magnesium and not aluminum by proton-induced X-ray emission spectroscopy. The structure adopted by GDP.MgF(-) possesses the stereochemistry and approximate charge expected for the transition state. We suggest that MgF3(-) may be the reagent of choice for studying phosphoryl transfer reactions.
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{{ABSTRACT_PUBMED_11927263}}
==About this Structure==
==About this Structure==
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[[Category: Gtpase]]
[[Category: Gtpase]]
[[Category: Transition state]]
[[Category: Transition state]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:22:54 2008''

Revision as of 00:23, 29 July 2008

Image:1ow3.png

Template:STRUCTURE 1ow3

Crystal Structure of RhoA.GDP.MgF3-in Complex with RhoGAP

Template:ABSTRACT PUBMED 11927263

About this Structure

1OW3 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

MgF(3)(-) as a transition state analog of phosphoryl transfer., Graham DL, Lowe PN, Grime GW, Marsh M, Rittinger K, Smerdon SJ, Gamblin SJ, Eccleston JF, Chem Biol. 2002 Mar;9(3):375-81. PMID:11927263

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