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1ovn

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{{STRUCTURE_1ovn| PDB=1ovn | SCENE= }}
{{STRUCTURE_1ovn| PDB=1ovn | SCENE= }}
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'''Crystal Structure and Functional Analysis of Drosophila Wind-- a PDI-Related Protein'''
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===Crystal Structure and Functional Analysis of Drosophila Wind-- a PDI-Related Protein===
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==Overview==
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In the developing Drosophila melanogaster embryo, dorsal-ventral patterning displays an absolute requirement for the product of the essential windbeutel gene, Wind. In homozygous windbeutel mutant flies, dorsal-ventral patterning fails to initiate because of the failure of the Golgi-resident proteoglycan-modifying protein, Pipe, to exit the endoplasmic reticulum, and this leads to the death of the embryo. Here, we describe the three-dimensional structure of Wind at 1.9-A resolution and identify a candidate surface for interaction with Pipe. This represents the first crystal structure of a eukaryotic protein-disulfide isomerase-related protein of the endoplasmic reticulum to be described. The dimeric protein is composed of an N-terminal thioredoxin domain and a C-terminal alpha-helical domain unique to protein-disulfide isomerase D proteins. Although Wind carries a CXXC motif that is partially surface accessible, this motif is redox inactive, and the cysteines are not required for the targeting of Pipe to the Golgi. However, both domains are required for targeting Pipe to the Golgi, and, although the mouse homologue ERp28 cannot replace the function of Wind, exchange of the Wind D-domain with that of ERp28 allows for efficient Golgi transport of Pipe.
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{{ABSTRACT_PUBMED_12941941}}
==About this Structure==
==About this Structure==
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[[Category: Wind]]
[[Category: Wind]]
[[Category: Windbeutel]]
[[Category: Windbeutel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:19:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:24:00 2008''

Revision as of 00:24, 29 July 2008

Image:1ovn.png

Template:STRUCTURE 1ovn

Crystal Structure and Functional Analysis of Drosophila Wind-- a PDI-Related Protein

Template:ABSTRACT PUBMED 12941941

About this Structure

1OVN is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Crystal structure and functional analysis of Drosophila Wind, a protein-disulfide isomerase-related protein., Ma Q, Guo C, Barnewitz K, Sheldrick GM, Soling HD, Uson I, Ferrari DM, J Biol Chem. 2003 Nov 7;278(45):44600-7. Epub 2003 Aug 26. PMID:12941941

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