1y4z

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[[Image:1y4z.gif|left|200px]]
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{{Seed}}
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[[Image:1y4z.png|left|200px]]
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{{STRUCTURE_1y4z| PDB=1y4z | SCENE= }}
{{STRUCTURE_1y4z| PDB=1y4z | SCENE= }}
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'''The crystal structure of Nitrate Reductase A, NarGHI, in complex with the Q-site inhibitor pentachlorophenol'''
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===The crystal structure of Nitrate Reductase A, NarGHI, in complex with the Q-site inhibitor pentachlorophenol===
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==Overview==
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The crystal structure of Escherichia coli nitrate reductase A (NarGHI) in complex with pentachlorophenol has been determined to 2.0 A of resolution. We have shown that pentachlorophenol is a potent inhibitor of quinol:nitrate oxidoreductase activity and that it also perturbs the EPR spectrum of one of the hemes located in the membrane anchoring subunit (NarI). This new structural information together with site-directed mutagenesis data, biochemical analyses, and molecular modeling provide the first molecular characterization of a quinol binding and oxidation site (Q-site) in NarGHI. A possible proton conduction pathway linked to electron transfer reactions has also been defined, providing fundamental atomic details of ubiquinol oxidation by NarGHI at the bacterial membrane.
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The line below this paragraph, {{ABSTRACT_PUBMED_15615728}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15615728 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15615728}}
==About this Structure==
==About this Structure==
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[[Category: Nitrate reduction]]
[[Category: Nitrate reduction]]
[[Category: Q-site]]
[[Category: Q-site]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:53:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:39:51 2008''

Revision as of 00:39, 29 July 2008

Image:1y4z.png

Template:STRUCTURE 1y4z

The crystal structure of Nitrate Reductase A, NarGHI, in complex with the Q-site inhibitor pentachlorophenol

Template:ABSTRACT PUBMED 15615728

About this Structure

1Y4Z is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural and biochemical characterization of a quinol binding site of Escherichia coli nitrate reductase A., Bertero MG, Rothery RA, Boroumand N, Palak M, Blasco F, Ginet N, Weiner JH, Strynadka NC, J Biol Chem. 2005 Apr 15;280(15):14836-43. Epub 2004 Dec 22. PMID:15615728

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