1x5v

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{{Seed}}
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{{STRUCTURE_1x5v| PDB=1x5v | SCENE= }}
{{STRUCTURE_1x5v| PDB=1x5v | SCENE= }}
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'''NMR Structure of PcFK1'''
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===NMR Structure of PcFK1===
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==Overview==
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Psalmopeotoxin I (PcFK1) is a 33-amino-acid residue peptide isolated from the venom of the tarantula Psalmopoeus cambridgei. It has been recently shown to possess strong antiplasmodial activity against the intra-erythrocyte stage of Plasmodium falciparum in vitro. Although the molecular target for PcFK1 is not yet determined, this peptide does not lyse erythrocytes, is not cytotoxic to nucleated mammalian cells, and does not inhibit neuromuscular function. We investigated the structural properties of PcFK1 to help understand the unique mechanism of action of this peptide and to enhance its utility as a lead compound for rational development of new antimalarial drugs. In this paper, we have determined the three-dimensional solution structure by (1)H two-dimensional NMR means of recombinant PcFK1, which is shown to belong to the ICK structural superfamily with structural determinants common to several neurotoxins acting as ion channels effectors.
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(as it appears on PubMed at http://www.pubmed.gov), where 16452619 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16452619}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5V OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5V OCA].
==Reference==
==Reference==
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[[Category: Pimentel, C.]]
[[Category: Pimentel, C.]]
[[Category: Inhibitory cystine knot]]
[[Category: Inhibitory cystine knot]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:36:00 2008''
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Revision as of 00:52, 29 July 2008

Image:1x5v.png

Template:STRUCTURE 1x5v

NMR Structure of PcFK1

Template:ABSTRACT PUBMED 16452619

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of PcFK1, a spider peptide active against Plasmodium falciparum., Pimentel C, Choi SJ, Chagot B, Guette C, Camadro JM, Darbon H, Protein Sci. 2006 Mar;15(3):628-34. Epub 2006 Feb 1. PMID:16452619

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