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1y5l

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[[Image:1y5l.gif|left|200px]]
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{{STRUCTURE_1y5l| PDB=1y5l | SCENE= }}
{{STRUCTURE_1y5l| PDB=1y5l | SCENE= }}
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'''The crystal structure of the NarGHI mutant NarI-H66Y'''
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===The crystal structure of the NarGHI mutant NarI-H66Y===
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==Overview==
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The crystal structure of Escherichia coli nitrate reductase A (NarGHI) in complex with pentachlorophenol has been determined to 2.0 A of resolution. We have shown that pentachlorophenol is a potent inhibitor of quinol:nitrate oxidoreductase activity and that it also perturbs the EPR spectrum of one of the hemes located in the membrane anchoring subunit (NarI). This new structural information together with site-directed mutagenesis data, biochemical analyses, and molecular modeling provide the first molecular characterization of a quinol binding and oxidation site (Q-site) in NarGHI. A possible proton conduction pathway linked to electron transfer reactions has also been defined, providing fundamental atomic details of ubiquinol oxidation by NarGHI at the bacterial membrane.
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(as it appears on PubMed at http://www.pubmed.gov), where 15615728 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15615728}}
==About this Structure==
==About this Structure==
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[[Category: Nitrate reduction]]
[[Category: Nitrate reduction]]
[[Category: Q-site]]
[[Category: Q-site]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:54:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:25:57 2008''

Revision as of 01:26, 29 July 2008

Image:1y5l.png

Template:STRUCTURE 1y5l

The crystal structure of the NarGHI mutant NarI-H66Y

Template:ABSTRACT PUBMED 15615728

About this Structure

1Y5L is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural and biochemical characterization of a quinol binding site of Escherichia coli nitrate reductase A., Bertero MG, Rothery RA, Boroumand N, Palak M, Blasco F, Ginet N, Weiner JH, Strynadka NC, J Biol Chem. 2005 Apr 15;280(15):14836-43. Epub 2004 Dec 22. PMID:15615728

Page seeded by OCA on Tue Jul 29 04:25:57 2008

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