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2org

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{{STRUCTURE_2org| PDB=2org | SCENE= }}
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'''Directing Macromolecular Conformation Through Halogen Bonds'''
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===Directing Macromolecular Conformation Through Halogen Bonds===
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==Overview==
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The halogen bond, a noncovalent interaction involving polarizable chlorine, bromine, or iodine molecular substituents, is now being exploited to control the assembly of small molecules in the design of supramolecular complexes and new materials. We demonstrate that a halogen bond formed between a brominated uracil and phosphate oxygen can be engineered to direct the conformation of a biological molecule, in this case to define the conformational isomer of a four-stranded DNA junction when placed in direct competition against a classic hydrogen bond. As a result, this bromine interaction is estimated to be approximately 2-5 kcal/mol stronger than the analogous hydrogen bond in this environment, depending on the geometry of the halogen bond. This study helps to establish halogen bonding as a potential tool for the rational design and construction of molecular materials with DNA and other biological macromolecules.
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(as it appears on PubMed at http://www.pubmed.gov), where 17379665 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17379665}}
==About this Structure==
==About this Structure==
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[[Category: Dna holliday junction]]
[[Category: Dna holliday junction]]
[[Category: Halogen bond]]
[[Category: Halogen bond]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:26:21 2008''

Revision as of 01:26, 29 July 2008

Image:2org.png

Template:STRUCTURE 2org

Directing Macromolecular Conformation Through Halogen Bonds

Template:ABSTRACT PUBMED 17379665

About this Structure

Full crystallographic information is available from OCA.

Reference

Directing macromolecular conformation through halogen bonds., Voth AR, Hays FA, Ho PS, Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6188-93. Epub 2007 Mar 22. PMID:17379665

Page seeded by OCA on Tue Jul 29 04:26:21 2008

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