1th0

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[[Image:1th0.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1th0| PDB=1th0 | SCENE= }}
{{STRUCTURE_1th0| PDB=1th0 | SCENE= }}
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'''Structure of human Senp2'''
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===Structure of human Senp2===
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==Overview==
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Modification of cellular proteins by the ubiquitin-like protein SUMO is essential for nuclear metabolism and cell cycle progression in yeast. X-ray structures of the human Senp2 catalytic protease domain and of a covalent thiohemiacetal transition-state complex obtained between the Senp2 catalytic domain and SUMO-1 revealed details of the respective protease and substrate surfaces utilized in interactions between these two proteins. Comparative biochemical and structural analysis between Senp2 and the yeast SUMO protease Ulp1 revealed differential abilities to process SUMO-1, SUMO-2, and SUMO-3 in maturation and deconjugation reactions. Further biochemical characterization of the three SUMO isoforms into which an additional Gly-Gly di-peptide was inserted, or whereby the respective SUMO tails from the three isoforms were swapped, suggests a strict dependence for SUMO isopeptidase activity on residues C-terminal to the conserved Gly-Gly motif and preferred cleavage site for SUMO proteases.
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The line below this paragraph, {{ABSTRACT_PUBMED_15296745}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15296745 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15296745}}
==About this Structure==
==About this Structure==
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[[Category: Sumo]]
[[Category: Sumo]]
[[Category: Ulp]]
[[Category: Ulp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:56:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:26:53 2008''

Revision as of 01:26, 29 July 2008

Image:1th0.png

Template:STRUCTURE 1th0

Structure of human Senp2

Template:ABSTRACT PUBMED 15296745

About this Structure

1TH0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex., Reverter D, Lima CD, Structure. 2004 Aug;12(8):1519-31. PMID:15296745

Page seeded by OCA on Tue Jul 29 04:26:53 2008

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