1zkz

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{{STRUCTURE_1zkz| PDB=1zkz | SCENE= }}
{{STRUCTURE_1zkz| PDB=1zkz | SCENE= }}
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'''Crystal Structure of BMP9'''
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===Crystal Structure of BMP9===
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==Overview==
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Bone morphogenetic proteins (BMPs), a subset of the transforming growth factor (TGF)-beta superfamily, regulate a diverse array of cellular functions during development and in the adult. BMP-9 (also known as growth and differentiation factor (GDF)-2) potently induces osteogenesis and chondrogenesis, has been implicated in the differentiation of cholinergic neurons, and may help regulate glucose metabolism. We have determined the structure of BMP-9 to 2.3 A and examined the differences between our model and existing crystal structures of other BMPs, both in isolation and in complex with their receptors. TGF-beta ligands are translated as precursors, with pro-regions that generally dissociate after cleavage from the ligand, but in some cases (including GDF-8 and TGF-beta1, -2, and -3), the pro-region remains associated after secretion from the cell and inhibits binding of the ligand to its receptor. Although the proregion of BMP-9 remains tightly associated after secretion, we find, in several cell-based assays, that the activities of BMP-9 and BMP-9.pro-region complex were equivalent. Activin receptor-like kinase 1 (ALK-1), an orphan receptor in the TGF-beta family, was also identified as a potential receptor for BMP-9 based on surface plasmon resonance studies (BIAcore) and the ability of soluble ALK-1 to block the activity of BMP-9.pro-region complex in cell-based assays.
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The line below this paragraph, {{ABSTRACT_PUBMED_15851468}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15851468 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15851468}}
==About this Structure==
==About this Structure==
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[[Category: Growth factor]]
[[Category: Growth factor]]
[[Category: Signal]]
[[Category: Signal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:45:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:28:37 2008''

Revision as of 01:28, 29 July 2008

Image:1zkz.png

Template:STRUCTURE 1zkz

Crystal Structure of BMP9

Template:ABSTRACT PUBMED 15851468

About this Structure

1ZKZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of BMP-9 and functional interactions with pro-region and receptors., Brown MA, Zhao Q, Baker KA, Naik C, Chen C, Pukac L, Singh M, Tsareva T, Parice Y, Mahoney A, Roschke V, Sanyal I, Choe S, J Biol Chem. 2005 Jul 1;280(26):25111-8. Epub 2005 Apr 25. PMID:15851468

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