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1pv4

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[[Image:1pv4.gif|left|200px]]
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{{STRUCTURE_1pv4| PDB=1pv4 | SCENE= }}
{{STRUCTURE_1pv4| PDB=1pv4 | SCENE= }}
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'''X-ray crystal structure of the Rho transcription termination factor in complex with single stranded DNA'''
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===X-ray crystal structure of the Rho transcription termination factor in complex with single stranded DNA===
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==Overview==
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In bacteria, one of the major transcriptional termination mechanisms requires a RNA/DNA helicase known as the Rho factor. We have determined two structures of Rho complexed with nucleic acid recognition site mimics in both free and nucleotide bound states to 3.0 A resolution. Both structures show that Rho forms a hexameric ring in which two RNA binding sites--a primary one responsible for target mRNA recognition and a secondary one required for mRNA translocation and unwinding--point toward the center of the ring. Rather than forming a closed ring, the Rho hexamer is split open, resembling a "lock washer" in its global architecture. The distance between subunits at the opening is sufficiently wide (12 A) to accommodate single-stranded RNA. This open configuration most likely resembles a state poised to load onto mRNA and suggests how related ring-shaped enzymes may be breached to bind nucleic acids.
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(as it appears on PubMed at http://www.pubmed.gov), where 12859904 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12859904}}
==About this Structure==
==About this Structure==
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[[Category: Skordalakes, E.]]
[[Category: Skordalakes, E.]]
[[Category: Protein-ssdna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:55:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:40:16 2008''

Revision as of 01:40, 29 July 2008

Image:1pv4.png

Template:STRUCTURE 1pv4

X-ray crystal structure of the Rho transcription termination factor in complex with single stranded DNA

Template:ABSTRACT PUBMED 12859904

About this Structure

1PV4 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the Rho transcription terminator: mechanism of mRNA recognition and helicase loading., Skordalakes E, Berger JM, Cell. 2003 Jul 11;114(1):135-46. PMID:12859904

Page seeded by OCA on Tue Jul 29 04:40:16 2008

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