2fd6

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{{STRUCTURE_2fd6| PDB=2fd6 | SCENE= }}
{{STRUCTURE_2fd6| PDB=2fd6 | SCENE= }}
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'''Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A'''
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===Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A===
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==Overview==
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The urokinase plasminogen activator binds to its cellular receptor with high affinity and initiates signaling cascades that are implicated in pathological processes including tumor growth, metastasis, and inflammation. We report the crystal structure at 1.9 angstroms of the urokinase receptor complexed with the urokinase amino-terminal fragment and an antibody against the receptor. The three domains of urokinase receptor form a concave shape with a central cone-shaped cavity where the urokinase fragment inserts. The structure provides insight into the flexibility of the urokinase receptor that enables its interaction with a wide variety of ligands and a basis for the design of urokinase-urokinase receptor antagonists.
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(as it appears on PubMed at http://www.pubmed.gov), where 16456079 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16456079}}
==About this Structure==
==About this Structure==
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[[Category: Ternary complex]]
[[Category: Ternary complex]]
[[Category: Upar]]
[[Category: Upar]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:45:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:46:08 2008''

Revision as of 01:46, 29 July 2008

Image:2fd6.png

Template:STRUCTURE 2fd6

Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A

Template:ABSTRACT PUBMED 16456079

About this Structure

2FD6 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of human urokinase plasminogen activator in complex with its receptor., Huai Q, Mazar AP, Kuo A, Parry GC, Shaw DE, Callahan J, Li Y, Yuan C, Bian C, Chen L, Furie B, Furie BC, Cines DB, Huang M, Science. 2006 Feb 3;311(5761):656-9. PMID:16456079

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