1qwf

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{{STRUCTURE_1qwf| PDB=1qwf | SCENE= }}
{{STRUCTURE_1qwf| PDB=1qwf | SCENE= }}
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'''C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND VSL12'''
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===C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND VSL12===
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==Overview==
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Two dodecapeptides belonging to distinct classes of Src homology 3 (SH3) ligands and selected from biased phage display libraries were used to investigate interactions between a specificity pocket in the Src SH3 domain and ligant residues flanking the proline-rich core. The solution structures of c-Src SH3 complexed with these peptides were solved by NMR. In addition to proline-rich, polyproline type II helix-forming core, the class I and II ligands each possesses a flanking sequence that occupies a large pocket between the RT and n-Src loops of the SH3 domain. Structural and mutational analyses illustrate how the two classes of SH3 ligands exploit a specificity pocket on the receptor differently to increase binding affinity and specificity.
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(as it appears on PubMed at http://www.pubmed.gov), where 8618911 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8618911}}
==About this Structure==
==About this Structure==
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1QWF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Avian_sarcoma_virus Avian sarcoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QWF OCA].
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1QWF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Avian_sarcoma_virus Avian sarcoma virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QWF OCA].
==Reference==
==Reference==
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[[Category: Class i ligand complex]]
[[Category: Class i ligand complex]]
[[Category: Src sh3 domain]]
[[Category: Src sh3 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:46:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:54:51 2008''

Revision as of 01:54, 29 July 2008

Image:1qwf.png

Template:STRUCTURE 1qwf

C-SRC SH3 DOMAIN COMPLEXED WITH LIGAND VSL12

Template:ABSTRACT PUBMED 8618911

About this Structure

1QWF is a Single protein structure of sequence from Avian sarcoma virus. Full experimental information is available from OCA.

Reference

Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands., Feng S, Kasahara C, Rickles RJ, Schreiber SL, Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12408-15. PMID:8618911

Page seeded by OCA on Tue Jul 29 04:54:51 2008

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