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331d

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{{STRUCTURE_331d| PDB=331d | SCENE= }}
{{STRUCTURE_331d| PDB=331d | SCENE= }}
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'''CRYSTAL STRUCTURE OF D(GCGCGCG) WITH 5'-OVERHANG G'S'''
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===CRYSTAL STRUCTURE OF D(GCGCGCG) WITH 5'-OVERHANG G'S===
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==Overview==
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The crystal structure of the DNA heptamer d(GCGCGCG) has been solved at 1.65 A resolution by the molecular replacement method and refined to an R-value of 0.184 for 3598 reflections. The heptamer forms a Z-DNA d(CGCGCG)2 with 5'-overhang G residues instead of an A-DNA d(GCGCGC)2 with 3'-overhang G residues. The overhang G residues from parallel strands of two adjacent duplexes form a trans reverse Hoogsteen G x G basepair that stacks on the six Z-DNA basepairs to produce a pseudocontinuous helix. The reverse Hoogsteen G x G basepair is unusual in that the displacement of one G base relative to the other allows them to participate in a bifurcated (G1)N2 . . . N7(G8) and an enhanced (G8)C8-H . . . O6(G1) hydrogen bond, in addition to the two usual hydrogen bonds. The 5'-overhang G residues are anti and C2'-endo while the 3'-terminal G residues are syn and C2'-endo. The conformations of both G residues are different from the syn/C3'-endo for the guanosine in a standard Z-DNA. The two cobalt hexammine ions bind to the phosphate groups in both GpC and CpG steps in Z(I) and Z(II) conformations. The water structure motif is similar to the other Z-DNA structures.
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(as it appears on PubMed at http://www.pubmed.gov), where 9284322 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9284322}}
==About this Structure==
==About this Structure==
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[[Category: Overhanging base]]
[[Category: Overhanging base]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:16:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:55:31 2008''

Revision as of 01:55, 29 July 2008

Image:331d.png

Template:STRUCTURE 331d

CRYSTAL STRUCTURE OF D(GCGCGCG) WITH 5'-OVERHANG G'S

Template:ABSTRACT PUBMED 9284322

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of d(GCGCGCG) with 5'-overhang G residues., Pan B, Ban C, Wahl MC, Sundaralingam M, Biophys J. 1997 Sep;73(3):1553-61. PMID:9284322

Page seeded by OCA on Tue Jul 29 04:55:31 2008

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