1jwg

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{{STRUCTURE_1jwg| PDB=1jwg | SCENE= }}
{{STRUCTURE_1jwg| PDB=1jwg | SCENE= }}
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'''VHS Domain of human GGA1 complexed with cation-independent M6PR C-terminal Peptide'''
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===VHS Domain of human GGA1 complexed with cation-independent M6PR C-terminal Peptide===
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==Overview==
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GGAs (Golgi-localizing, gamma-adaptin ear homology domain, ARF-interacting proteins) are critical for the transport of soluble proteins from the trans-Golgi network (TGN) to endosomes/lysosomes by means of interactions with TGN-sorting receptors, ADP-ribosylation factor (ARF), and clathrin. The amino-terminal VHS domains of GGAs form complexes with the cytoplasmic domains of sorting receptors by recognizing acidic-cluster dileucine (ACLL) sequences. Here we report the X-ray structure of the GGA1 VHS domain alone, and in complex with the carboxy-terminal peptide of cation-independent mannose 6-phosphate receptor containing an ACLL sequence. The VHS domain forms a super helix with eight alpha-helices, similar to the VHS domains of TOM1 and Hrs. Unidirectional movements of helices alpha6 and alpha8, and some of their side chains, create a set of electrostatic and hydrophobic interactions for correct recognition of the ACLL peptide. This recognition mechanism provides the basis for regulation of protein transport from the TGN to endosomes/lysosomes, which is shared by sortilin and low-density lipoprotein receptor-related protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 11859376 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11859376}}
==About this Structure==
==About this Structure==
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[[Category: Protein-peptide complex]]
[[Category: Protein-peptide complex]]
[[Category: Super helix]]
[[Category: Super helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:00:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:24:41 2008''

Revision as of 02:24, 29 July 2008

Image:1jwg.png

Template:STRUCTURE 1jwg

VHS Domain of human GGA1 complexed with cation-independent M6PR C-terminal Peptide

Template:ABSTRACT PUBMED 11859376

About this Structure

1JWG is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for recognition of acidic-cluster dileucine sequence by GGA1., Shiba T, Takatsu H, Nogi T, Matsugaki N, Kawasaki M, Igarashi N, Suzuki M, Kato R, Earnest T, Nakayama K, Wakatsuki S, Nature. 2002 Feb 21;415(6874):937-41. PMID:11859376

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