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| - | [[Image:2fys.gif|left|200px]] | + | {{Seed}} |
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| | {{STRUCTURE_2fys| PDB=2fys | SCENE= }} | | {{STRUCTURE_2fys| PDB=2fys | SCENE= }} |
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| - | '''Crystal structure of Erk2 complex with KIM peptide derived from MKP3'''
| + | ===Crystal structure of Erk2 complex with KIM peptide derived from MKP3=== |
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| - | ==Overview==
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| - | Mitogen-activated protein (MAP) kinases are central components of signal transduction pathways for cell proliferation, stress responses, and differentiation. Signaling efficiency and specificity are modulated in large part by docking interactions between individual MAP kinase and the kinase interaction motif (KIM), (R/K)(2-3)-X(1-6)-Phi(A)-X-Phi(B), in its cognate kinases, phosphatases, scaffolding proteins, and substrates. We have determined the crystal structure of extracellular signal-regulated protein kinase 2 bound to the KIM peptide from MAP kinase phosphatase 3, an extracellular signal-regulated protein kinase 2-specific phosphatase. The structure reveals that the KIM docking site, situated in a noncatalytic region opposite of the kinase catalytic pocket, is comprised of a highly acidic patch and a hydrophobic groove, which engage the basic and Phi(A)-X-Phi(B) residues, respectively, in the KIM sequence. The specific docking interactions observed in the structure consolidate all known biochemical data. In addition, structural comparison indicates that the KIM docking site is conserved in all MAP kinases. The results establish a structural model for understanding how MAP kinases interact with their regulators and substrates and provide new insights into how MAP kinase docking specificity can be achieved.
| + | The line below this paragraph, {{ABSTRACT_PUBMED_16567630}}, adds the Publication Abstract to the page |
| | + | (as it appears on PubMed at http://www.pubmed.gov), where 16567630 is the PubMed ID number. |
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| | + | {{ABSTRACT_PUBMED_16567630}} |
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| | ==About this Structure== | | ==About this Structure== |
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| | [[Category: Map kinase]] | | [[Category: Map kinase]] |
| | [[Category: Mkp3]] | | [[Category: Mkp3]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:27:50 2008'' | + | |
| | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:48:08 2008'' |
Revision as of 02:48, 29 July 2008
Template:STRUCTURE 2fys
Crystal structure of Erk2 complex with KIM peptide derived from MKP3
Template:ABSTRACT PUBMED 16567630
About this Structure
2FYS is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3., Liu S, Sun JP, Zhou B, Zhang ZY, Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5326-31. Epub 2006 Mar 27. PMID:16567630
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