2ez0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2ez0.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2ez0.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2ez0| PDB=2ez0 | SCENE= }}
{{STRUCTURE_2ez0| PDB=2ez0 | SCENE= }}
-
'''Crystal structure of the S107A/E148Q/Y445A mutant of EcClC, in complex with a FaB fragment'''
+
===Crystal structure of the S107A/E148Q/Y445A mutant of EcClC, in complex with a FaB fragment===
-
==Overview==
+
<!--
-
The ClC channels are members of a large protein family of chloride (Cl-) channels and secondary active Cl- transporters. Despite their diverse functions, the transmembrane architecture within the family is conserved. Here we present a crystallographic study on the ion-binding properties of the ClC selectivity filter in the close homolog from Escherichia coli (EcClC). The ClC selectivity filter contains three ion-binding sites that bridge the extra- and intracellular solutions. The sites bind Cl- ions with mM affinity. Despite their close proximity within the filter, the three sites can be occupied simultaneously. The ion-binding properties are found conserved from the bacterial transporter EcClC to the human Cl- channel ClC-1, suggesting a close functional link between ion permeation in the channels and active transport in the transporters. In resemblance to K+ channels, ions permeate the ClC channel in a single file, with mutual repulsion between the ions fostering rapid conduction.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16341087}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16341087 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16341087}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: H+/cl- antiporter]]
[[Category: H+/cl- antiporter]]
[[Category: Membrane protein/fab complex]]
[[Category: Membrane protein/fab complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:16:13 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:01:52 2008''

Revision as of 03:01, 29 July 2008

Image:2ez0.png

Template:STRUCTURE 2ez0

Crystal structure of the S107A/E148Q/Y445A mutant of EcClC, in complex with a FaB fragment

Template:ABSTRACT PUBMED 16341087

About this Structure

2EZ0 is a Single protein structure of sequence from Escherichia coli and Mus musculus. Full crystallographic information is available from OCA.

Reference

Ion-binding properties of the ClC chloride selectivity filter., Lobet S, Dutzler R, EMBO J. 2006 Jan 11;25(1):24-33. Epub 2005 Dec 8. PMID:16341087

Page seeded by OCA on Tue Jul 29 06:01:52 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ez0"
Personal tools