1q1f

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1q1f.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1q1f.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1q1f| PDB=1q1f | SCENE= }}
{{STRUCTURE_1q1f| PDB=1q1f | SCENE= }}
-
'''Crystal structure of murine neuroglobin'''
+
===Crystal structure of murine neuroglobin===
-
==Overview==
+
<!--
-
Neuroglobin, a recently discovered globin predominantly expressed in neuronal tissue of vertebrates, binds small, gaseous ligands at the sixth coordination position of the heme iron. In the absence of an exogenous ligand, the distal histidine (His64) binds to the heme iron in the ferrous and ferric states. The crystal structure of murine ferric (met) neuroglobin at 1.5 A reveals interesting features relevant to the ligand binding mechanism. Only weak selectivity is observed for the two possible heme orientations, the occupancy ratio being 70:30. Two small internal cavities are present on the heme distal side, which enable the His64(E7) side chain to move out of the way upon exogenous ligand binding. Moreover, a third, huge cavity (volume approximately 290 A3) connecting both sides of the heme, is open towards the exterior and provides a potential passageway for ligands. The CD and EF corners exhibit substantial flexibility, which may assist ligands in entering the protein and accessing the active site. Based on this high-resolution structure, further structure-function studies can be planned to elucidate the role of neuroglobin in physiological responses to hypoxia.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15162488}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15162488 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15162488}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Heme protein]]
[[Category: Heme protein]]
[[Category: Neuroglobin]]
[[Category: Neuroglobin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:44:57 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:02:51 2008''

Revision as of 03:02, 29 July 2008

Image:1q1f.png

Template:STRUCTURE 1q1f

Crystal structure of murine neuroglobin

Template:ABSTRACT PUBMED 15162488

About this Structure

1Q1F is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of murine neuroglobin: Novel pathways for ligand migration and binding., Vallone B, Nienhaus K, Brunori M, Nienhaus GU, Proteins. 2004 Jul 1;56(1):85-92. PMID:15162488

Page seeded by OCA on Tue Jul 29 06:02:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1q1f"
Personal tools