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1szw

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{{STRUCTURE_1szw| PDB=1szw | SCENE= }}
{{STRUCTURE_1szw| PDB=1szw | SCENE= }}
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'''Crystal structure of E. coli tRNA pseudouridine synthase TruD'''
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===Crystal structure of E. coli tRNA pseudouridine synthase TruD===
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==Overview==
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Pseudouridine synthases catalyse the isomerisation of uridine to pseudouridine in structural RNA. The pseudouridine synthase TruD, that modifies U13 in tRNA, belongs to a recently identified and large family of pseudouridine synthases present in all kingdoms of life. We report here the crystal structure of Escherichia coli TruD at 2.0 A resolution. The structure reveals an overall V-shaped molecule with an RNA-binding cleft formed between two domains: a catalytic domain and an insertion domain. The catalytic domain has a fold similar to that of the catalytic domains of previously characterised pseudouridine synthases, whereas the insertion domain displays a novel fold.
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{{ABSTRACT_PUBMED_15135053}}
==About this Structure==
==About this Structure==
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[[Category: Structural proteomics in europe]]
[[Category: Structural proteomics in europe]]
[[Category: Trud]]
[[Category: Trud]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:11:34 2008''
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Revision as of 03:06, 29 July 2008

Image:1szw.png

Template:STRUCTURE 1szw

Crystal structure of E. coli tRNA pseudouridine synthase TruD

Template:ABSTRACT PUBMED 15135053

About this Structure

1SZW is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold., Ericsson UB, Nordlund P, Hallberg BM, FEBS Lett. 2004 May 7;565(1-3):59-64. PMID:15135053

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