2ja5

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{{STRUCTURE_2ja5| PDB=2ja5 | SCENE= }}
{{STRUCTURE_2ja5| PDB=2ja5 | SCENE= }}
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'''CPD LESION CONTAINING RNA POLYMERASE II ELONGATION COMPLEX A'''
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===CPD LESION CONTAINING RNA POLYMERASE II ELONGATION COMPLEX A===
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==Overview==
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Cells use transcription-coupled repair (TCR) to efficiently eliminate DNA lesions such as ultraviolet light-induced cyclobutane pyrimidine dimers (CPDs). Here we present the structure-based mechanism for the first step in eukaryotic TCR, CPD-induced stalling of RNA polymerase (Pol) II. A CPD in the transcribed strand slowly passes a translocation barrier and enters the polymerase active site. The CPD 5'-thymine then directs uridine misincorporation into messenger RNA, which blocks translocation. Artificial replacement of the uridine by adenosine enables CPD bypass; thus, Pol II stalling requires CPD-directed misincorporation. In the stalled complex, the lesion is inaccessible, and the polymerase conformation is unchanged. This is consistent with nonallosteric recruitment of repair factors and excision of a lesion-containing DNA fragment in the presence of Pol II.
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(as it appears on PubMed at http://www.pubmed.gov), where 17290000 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17290000}}
==About this Structure==
==About this Structure==
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:35:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:25:24 2008''

Revision as of 03:25, 29 July 2008

Image:2ja5.png

Template:STRUCTURE 2ja5

CPD LESION CONTAINING RNA POLYMERASE II ELONGATION COMPLEX A

Template:ABSTRACT PUBMED 17290000

About this Structure

2JA5 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

CPD damage recognition by transcribing RNA polymerase II., Brueckner F, Hennecke U, Carell T, Cramer P, Science. 2007 Feb 9;315(5813):859-62. PMID:17290000

Page seeded by OCA on Tue Jul 29 06:25:24 2008

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