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259d

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{{STRUCTURE_259d| PDB=259d | SCENE= }}
{{STRUCTURE_259d| PDB=259d | SCENE= }}
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'''RNA HYDRATION: A DETAILED LOOK'''
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===RNA HYDRATION: A DETAILED LOOK===
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==Overview==
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The crystal structure of the RNA duplex [r(CCCCGGGG)]2 has been refined to 1.46 A resolution with room temperature synchrotron diffraction data. This represents the highest resolution reported to date for an all-RNA oligonucleotide and is well beyond the best resolution ever achieved with an A-form DNA duplex. The analysis of the ordered hydration around the octamer duplex reveals conserved regular arrangements of water molecules in both grooves. In the major groove, all located first shell water molecules can be fitted into a pattern that is repeated through all eight base pairs, involves half the phosphate oxygens, and joins the two strands. In the minor groove, roughly across its narrowest dimension, tandem water molecules link the 2'-hydroxyl groups of adjacent nucleotides in base-pair steps in a similarly regular fashion. The structure provides evidence for an important role of the 2'-hydroxyl groups in the thermodynamic stabilization of RNA, beyond their known functions of locking the sugar pucker and mediating 3' --&gt; 5' intrastrand O2'...O4' hydrogen bonds. The ribose 2'-hydroxyls lay the foundation for the enthalpic stability of the RNA relative to the DNA duplex, both as a scaffold for the water network in the minor groove and through their extensive individual hydration.
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{{ABSTRACT_PUBMED_8679609}}
==About this Structure==
==About this Structure==
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[[Category: A-rna]]
[[Category: A-rna]]
[[Category: Double helix]]
[[Category: Double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:24:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:25:59 2008''

Revision as of 03:26, 29 July 2008

Image:259d.png

Template:STRUCTURE 259d

RNA HYDRATION: A DETAILED LOOK

Template:ABSTRACT PUBMED 8679609

About this Structure

Full crystallographic information is available from OCA.

Reference

RNA hydration: a detailed look., Egli M, Portmann S, Usman N, Biochemistry. 1996 Jul 2;35(26):8489-94. PMID:8679609

Page seeded by OCA on Tue Jul 29 06:25:59 2008

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