1xt0

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{{STRUCTURE_1xt0| PDB=1xt0 | SCENE= }}
{{STRUCTURE_1xt0| PDB=1xt0 | SCENE= }}
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'''The Structure of N-terminal Sec7 domain of RalF'''
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===The Structure of N-terminal Sec7 domain of RalF===
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==Overview==
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The Legionella pneumophila protein RalF is secreted into host cytosol via the Dot/Icm type IV transporter where it acts to recruit ADP-ribosylation factor (Arf) to pathogen-containing phagosomes in the establishment of a replicative organelle. The presence in RalF of the Sec7 domain, present in all Arf guanine nucleotide exchange factors, has suggested that recruitment of Arf is an early step in pathogenesis. We have determined the crystal structure of RalF and of the isolated Sec7 domain and found that RalF is made up of two domains. The Sec7 domain is homologous to mammalian Sec7 domains. The C-terminal domain forms a cap over the active site in the Sec7 domain and contains a conserved folding motif, previously observed in adaptor subunits of vesicle coat complexes. The importance of the capping domain and of the glutamate in the "glutamic finger," conserved in all Sec7 domains, to RalF functions was examined using three different assays. These data highlight the functional importance of domains other than Sec7 in Arf guanine nucleotide exchange factors to biological activities and suggest novel mechanisms of regulation of those activities.
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{{ABSTRACT_PUBMED_15520000}}
==About this Structure==
==About this Structure==
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[[Category: Swails, J.]]
[[Category: Swails, J.]]
[[Category: The n-terminal sec7 domain of ralf]]
[[Category: The n-terminal sec7 domain of ralf]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:27:42 2008''

Revision as of 03:27, 29 July 2008

Image:1xt0.png

Template:STRUCTURE 1xt0

The Structure of N-terminal Sec7 domain of RalF

Template:ABSTRACT PUBMED 15520000

About this Structure

1XT0 is a Single protein structure of sequence from Legionella pneumophila. Full crystallographic information is available from OCA.

Reference

The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site., Amor JC, Swails J, Zhu X, Roy CR, Nagai H, Ingmundson A, Cheng X, Kahn RA, J Biol Chem. 2005 Jan 14;280(2):1392-400. Epub 2004 Nov 1. PMID:15520000

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