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2b8a

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[[Image:2b8a.gif|left|200px]]
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{{STRUCTURE_2b8a| PDB=2b8a | SCENE= }}
{{STRUCTURE_2b8a| PDB=2b8a | SCENE= }}
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'''High Resolution Structure of the HDGF PWWP Domain'''
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===High Resolution Structure of the HDGF PWWP Domain===
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==Overview==
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Hepatoma Derived Growth Factor (HDGF) is an endogenous nuclear-targeted mitogen that is linked with human disease. HDGF is a member of the weakly conserved PWWP domain family. This 70-amino acid motif, originally identified from the WHSC1 gene, has been found in more than 60 eukaryotic proteins. In addition to the PWWP domain, many proteins in this class contain known chromatin remodeling domains, suggesting a role for HDGF in chromatin remodeling. We have determined the NMR structure of the HDGF PWWP domain to high resolution using a combination of NOEs, J-couplings, and dipolar couplings. Comparison of this structure to a previously determined structure of the HDGF PWWP domain shows a significant difference in the C-terminal region. Comparison to structures of other PWWP domains shows a high degree of similarity to the PWWP domain structures from Dnmt3b and mHRP. The results of selected and amplified binding assay and NMR titrations with DNA suggest that the HDGF PWWP domain may function as a nonspecific DNA-binding domain. Based on the NMR titrations, we propose a model of the interaction of the PWWP domain with DNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 16384999 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16384999}}
==About this Structure==
==About this Structure==
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2B8A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA].
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2B8A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA].
==Reference==
==Reference==
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[[Category: Hdgf]]
[[Category: Hdgf]]
[[Category: Pwwp]]
[[Category: Pwwp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:58:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:40:15 2008''

Revision as of 03:40, 29 July 2008

Image:2b8a.png

Template:STRUCTURE 2b8a

High Resolution Structure of the HDGF PWWP Domain

Template:ABSTRACT PUBMED 16384999

About this Structure

2B8A is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

High resolution structure of the HDGF PWWP domain: a potential DNA binding domain., Lukasik SM, Cierpicki T, Borloz M, Grembecka J, Everett A, Bushweller JH, Protein Sci. 2006 Feb;15(2):314-23. Epub 2005 Dec 29. PMID:16384999

Page seeded by OCA on Tue Jul 29 06:40:15 2008

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