2dw2

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{{STRUCTURE_2dw2| PDB=2dw2 | SCENE= }}
{{STRUCTURE_2dw2| PDB=2dw2 | SCENE= }}
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'''Crystal structure of VAP2 from Crotalus atrox venom (Form 2-5 crystal)'''
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===Crystal structure of VAP2 from Crotalus atrox venom (Form 2-5 crystal)===
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==Overview==
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Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a metalloproteinase from Crotalus atrox venom, possessing metalloproteinase/disintegrin/cysteine-rich (MDC) domains that bear the typical domain architecture of a disintegrin and metalloproteinase (ADAM)/adamalysin/reprolysin family proteins. Here we describe crystal structures of catrocollastatin/VAP2B in three different crystal forms, representing the first reported crystal structures of a member of the monomeric class of this family of proteins. The overall structures show good agreement with both monomers of atypical homodimeric VAP1. Comparison of the six catrocollastatin/VAP2B monomer structures and the structures of VAP1 reveals a dynamic, modular architecture that may be important for the functions of ADAM/adamalysin/reprolysin family proteins.
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{{ABSTRACT_PUBMED_17485084}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins., Igarashi T, Araki S, Mori H, Takeda S, FEBS Lett. 2007 May 29;581(13):2416-22. Epub 2007 Apr 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17485084 17485084]
Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins., Igarashi T, Araki S, Mori H, Takeda S, FEBS Lett. 2007 May 29;581(13):2416-22. Epub 2007 Apr 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17485084 17485084]
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Crystallization and preliminary X-ray crystallographic analysis of two vascular apoptosis-inducing proteins (VAPs) from Crotalus atrox venom., Igarashi T, Oishi Y, Araki S, Mori H, Takeda S, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt, 7):688-91. Epub 2006 Jun 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16820695 16820695]
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Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold., Takeda S, Igarashi T, Mori H, Araki S, EMBO J. 2006 Jun 7;25(11):2388-96. Epub 2006 May 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16688218 16688218]
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cDNA cloning and some additional peptide characterization of a single-chain vascular apoptosis-inducing protein, VAP2., Masuda S, Maeda H, Miao JY, Hayashi H, Araki S, Endothelium. 2007 Mar-Apr;14(2):89-96. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17497365 17497365]
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Two vascular apoptosis-inducing proteins from snake venom are members of the metalloprotease/disintegrin family., Masuda S, Hayashi H, Araki S, Eur J Biochem. 1998 Apr 1;253(1):36-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9578458 9578458]
[[Category: Crotalus atrox]]
[[Category: Crotalus atrox]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Metalloproteinase]]
[[Category: Metalloproteinase]]
[[Category: Svmp]]
[[Category: Svmp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:29:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:01:20 2008''

Revision as of 04:01, 29 July 2008

Image:2dw2.png

Template:STRUCTURE 2dw2

Crystal structure of VAP2 from Crotalus atrox venom (Form 2-5 crystal)

Template:ABSTRACT PUBMED 17485084

About this Structure

2DW2 is a Single protein structure of sequence from Crotalus atrox. Full crystallographic information is available from OCA.

Reference

Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins., Igarashi T, Araki S, Mori H, Takeda S, FEBS Lett. 2007 May 29;581(13):2416-22. Epub 2007 Apr 30. PMID:17485084

Crystallization and preliminary X-ray crystallographic analysis of two vascular apoptosis-inducing proteins (VAPs) from Crotalus atrox venom., Igarashi T, Oishi Y, Araki S, Mori H, Takeda S, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt, 7):688-91. Epub 2006 Jun 26. PMID:16820695

Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold., Takeda S, Igarashi T, Mori H, Araki S, EMBO J. 2006 Jun 7;25(11):2388-96. Epub 2006 May 11. PMID:16688218

cDNA cloning and some additional peptide characterization of a single-chain vascular apoptosis-inducing protein, VAP2., Masuda S, Maeda H, Miao JY, Hayashi H, Araki S, Endothelium. 2007 Mar-Apr;14(2):89-96. PMID:17497365

Two vascular apoptosis-inducing proteins from snake venom are members of the metalloprotease/disintegrin family., Masuda S, Hayashi H, Araki S, Eur J Biochem. 1998 Apr 1;253(1):36-41. PMID:9578458

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