This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1pq7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1pq7.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1pq7.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1pq7| PDB=1pq7 | SCENE= }}
{{STRUCTURE_1pq7| PDB=1pq7 | SCENE= }}
-
'''Trypsin at 0.8 A, pH5 / borax'''
+
===Trypsin at 0.8 A, pH5 / borax===
-
==Overview==
+
<!--
-
A series of crystal structures of trypsin, containing either an autoproteolytic cleaved peptide fragment or a covalently bound inhibitor, were determined at atomic and ultra-high resolution and subjected to ab initio quantum chemical calculations and multipole refinement. Quantum chemical calculations reproduced the observed active site crystal structure with severe deviations from standard stereochemistry and indicated the protonation state of the catalytic residues. Multipole refinement directly revealed the charge distribution in the active site and proved the validity of the ab initio calculations. The combined results confirmed the catalytic function of the active site residues and the two water molecules acting as the nucleophile and the proton donor. The crystal structures represent snapshots from the reaction pathway, close to a tetrahedral intermediate. The de-acylation of trypsin then occurs in true SN2 fashion.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12937176}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12937176 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12937176}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Trypsin]]
[[Category: Trypsin]]
[[Category: Ultra-high resolution]]
[[Category: Ultra-high resolution]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:21:36 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:02:21 2008''

Revision as of 04:02, 29 July 2008

Image:1pq7.png

Template:STRUCTURE 1pq7

Trypsin at 0.8 A, pH5 / borax

Template:ABSTRACT PUBMED 12937176

About this Structure

1PQ7 is a Single protein structure of sequence from Fusarium oxysporum. Full crystallographic information is available from OCA.

Reference

Trypsin revisited: crystallography AT (SUB) atomic resolution and quantum chemistry revealing details of catalysis., Schmidt A, Jelsch C, Ostergaard P, Rypniewski W, Lamzin VS, J Biol Chem. 2003 Oct 31;278(44):43357-62. Epub 2003 Aug 22. PMID:12937176

Page seeded by OCA on Tue Jul 29 07:02:21 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pq7"
Personal tools