This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2eif

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2eif.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2eif.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2eif| PDB=2eif | SCENE= }}
{{STRUCTURE_2eif| PDB=2eif | SCENE= }}
-
'''Eukaryotic translation initiation factor 5A from Methanococcus jannaschii'''
+
===Eukaryotic translation initiation factor 5A from Methanococcus jannaschii===
-
==Overview==
+
<!--
-
Eukaryotic translation initiation factor 5A (eIF-5A) is a ubiquitous protein found in all eukaryotic cells. The protein is closely associated with cell proliferation in the G1-S stage of the cell cycle. Recent findings show that the eIF-5A proteins are highly expressed in tumor cells and act as a cofactor of the Rev protein in HIV-1-infected cells. The mature eIF is the only protein known to have the unusual amino acid hypusine, a post-translationally modified lysine. The crystal structure of eIF-5A from Methanococcus jannaschii (MJ eIF-5A) has been determined at 1.9 A and 1.8 A resolution in two crystal forms by using the multiple isomorphous replacement method and the multiwavelength anomalous diffraction method for the first crystal form and the molecular replacement method for the second crystal form. The structure consists of two folding domains, one of which is similar to the oligonucleotide-binding domain found in the prokaryotic cold shock protein and the translation initiation factor IF1 despite the absence of any significant sequence similarities. The 12 highly conserved amino acid residues found among eIF-5As include the hypusine site and form a long protruding loop at one end of the elongated molecule.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9724718}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9724718 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9724718}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Translation]]
[[Category: Translation]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 02:35:50 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:19:35 2008''

Revision as of 04:19, 29 July 2008

Image:2eif.png

Template:STRUCTURE 2eif

Eukaryotic translation initiation factor 5A from Methanococcus jannaschii

Template:ABSTRACT PUBMED 9724718

About this Structure

2EIF is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Crystal structures of eukaryotic translation initiation factor 5A from Methanococcus jannaschii at 1.8 A resolution., Kim KK, Hung LW, Yokota H, Kim R, Kim SH, Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10419-24. PMID:9724718

Page seeded by OCA on Tue Jul 29 07:19:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2eif"
Personal tools