This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2b5a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2b5a.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2b5a.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2b5a| PDB=2b5a | SCENE= }}
{{STRUCTURE_2b5a| PDB=2b5a | SCENE= }}
-
'''C.BclI, Control Element of the BclI Restriction-Modification System'''
+
===C.BclI, Control Element of the BclI Restriction-Modification System===
-
==Overview==
+
<!--
-
Protection from DNA invasion is afforded by restriction-modification systems in many bacteria. The efficiency of protection depends crucially on the relative expression levels of restriction versus methytransferase genes. This regulation is provided by a controller protein, named C protein. Studies of the Bcll system in E. coli suggest that C.Bcll functions as a negative regulator for M.Bcll expression, implying that it plays a role in defense against foreign DNA during virus infection. C.Bcll binds (Kd = 14.3 nM) to a 2-fold symmetric C box DNA sequence that overlaps with the putative -35 promoter region upstream of the bcllM and bcllC genes. The C.Bcll fold comprises five alpha helices: two helices form a helix-turn-helix motif, and the remaining three helices form the extensive dimer interface. The C.Bcll-DNA model proposed suggests that DNA bending might play an important role in gene regulation, and that Glu27 and Asp31 in C.Bcll might function critically in the regulation.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16338412}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16338412 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16338412}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Zhu, Z.]]
[[Category: Zhu, Z.]]
[[Category: Helix-turn-helix motif]]
[[Category: Helix-turn-helix motif]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:52:28 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:23:10 2008''

Revision as of 04:23, 29 July 2008

Image:2b5a.png

Template:STRUCTURE 2b5a

C.BclI, Control Element of the BclI Restriction-Modification System

Template:ABSTRACT PUBMED 16338412

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of the restriction-modification system control element C.Bcll and mapping of its binding site., Sawaya MR, Zhu Z, Mersha F, Chan SH, Dabur R, Xu SY, Balendiran GK, Structure. 2005 Dec;13(12):1837-47. PMID:16338412

Page seeded by OCA on Tue Jul 29 07:23:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b5a"
Personal tools