1v7f

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[[Image:1v7f.jpg|left|200px]]
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{{Seed}}
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[[Image:1v7f.png|left|200px]]
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{{STRUCTURE_1v7f| PDB=1v7f | SCENE= }}
{{STRUCTURE_1v7f| PDB=1v7f | SCENE= }}
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'''solution structure of phrixotoxin 1'''
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===solution structure of phrixotoxin 1===
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==Overview==
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Animal toxins block voltage-dependent potassium channels (Kv) either by occluding the conduction pore (pore blockers) or by modifying the channel gating properties (gating modifiers). Gating modifiers of Kv channels bind to four equivalent extracellular sites near the S3 and S4 segments, close to the voltage sensor. Phrixotoxins are gating modifiers that bind preferentially to the closed state of the channel and fold into the Inhibitory Cystine Knot structural motif. We have solved the solution structure of Phrixotoxin 1, a gating modifier of Kv4 potassium channels. Analysis of the molecular surface and the electrostatic anisotropy of Phrixotoxin 1 and of other toxins acting on voltage-dependent potassium channels allowed us to propose a toxin interacting surface that encompasses both the surface from which the dipole moment emerges and a neighboring hydrophobic surface rich in aromatic residues.
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The line below this paragraph, {{ABSTRACT_PUBMED_15096626}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15096626 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15096626}}
==About this Structure==
==About this Structure==
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1V7F is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V7F OCA].
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1V7F is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V7F OCA].
==Reference==
==Reference==
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[[Category: Villegas, E.]]
[[Category: Villegas, E.]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:10:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:57:18 2008''

Revision as of 04:57, 29 July 2008

Image:1v7f.png

Template:STRUCTURE 1v7f

solution structure of phrixotoxin 1

Template:ABSTRACT PUBMED 15096626

About this Structure

1V7F is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus., Chagot B, Escoubas P, Villegas E, Bernard C, Ferrat G, Corzo G, Lazdunski M, Darbon H, Protein Sci. 2004 May;13(5):1197-208. PMID:15096626

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