2boj

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{{STRUCTURE_2boj| PDB=2boj | SCENE= }}
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'''CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN (PA-IIL) COMPLEXED WITH METHYL-B-D-ARABINOPYRANOSIDE'''
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===CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN (PA-IIL) COMPLEXED WITH METHYL-B-D-ARABINOPYRANOSIDE===
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==Overview==
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The lectin from Pseudomonas aeruginosa (PA-IIL) is involved in host recognition and biofilm formation. Lectin not only displays an unusually high affinity for fucose but also binds to L-fucose, L-galactose and D-arabinose that differ only by the group at position 5 of the sugar ring. Isothermal calorimetry experiments provided precise determination of affinity for the three methyl-glycosides and revealed a large enthalpy contribution. The crystal structures of the complexes of PA-IIL with L-galactose and Met-beta-D-arabinoside have been determined and compared with the PA-IIL/fucose complex described previously. A combination of the structures and thermodynamics provided clues for the role of the hydrophobic group in affinity.
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(as it appears on PubMed at http://www.pubmed.gov), where 16438968 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16438968}}
==About this Structure==
==About this Structure==
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[[Category: Wimmerova, M.]]
[[Category: Wimmerova, M.]]
[[Category: Lectin,arabinose,calcium,lewis a,cystic fibrosis]]
[[Category: Lectin,arabinose,calcium,lewis a,cystic fibrosis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:34:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:37:59 2008''

Revision as of 05:38, 29 July 2008

Image:2boj.png

Template:STRUCTURE 2boj

CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN (PA-IIL) COMPLEXED WITH METHYL-B-D-ARABINOPYRANOSIDE

Template:ABSTRACT PUBMED 16438968

About this Structure

2BOJ is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Binding of different monosaccharides by lectin PA-IIL from Pseudomonas aeruginosa: thermodynamics data correlated with X-ray structures., Sabin C, Mitchell EP, Pokorna M, Gautier C, Utille JP, Wimmerova M, Imberty A, FEBS Lett. 2006 Feb 6;580(3):982-7. Epub 2006 Jan 19. PMID:16438968

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