This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2jvb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2jvb.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2jvb.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2jvb| PDB=2jvb | SCENE= }}
{{STRUCTURE_2jvb| PDB=2jvb | SCENE= }}
-
'''Solution Structure of Catalytic Domain of yDcp2'''
+
===Solution Structure of Catalytic Domain of yDcp2===
-
==Overview==
+
<!--
-
Cap hydrolysis by Dcp2 is a critical step in several eukaryotic mRNA decay pathways. Processing requires access to cap-proximal nucleotides and the coordinated assembly of a decapping mRNP, but the mechanism of substrate recognition and regulation by protein interactions have remained elusive. Using NMR spectroscopy and kinetic analyses, we show that yeast Dcp2 resolves interactions with the cap and RNA body using a bipartite surface that forms a channel intersecting the catalytic and regulatory Dcp1-binding domains. The interaction with cap is weak but specific and requires binding of the RNA body to a dynamic interface. The catalytic step is stimulated by Dcp1 and its interaction domain, likely through a substrate-induced conformational change. Thus, activation of the decapping mRNP is restricted by access to 5'-proximal nucleotides, a feature that could act as a checkpoint in mRNA metabolism.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18280238}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18280238 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18280238}}
==About this Structure==
==About this Structure==
-
2JVB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JVB OCA].
+
2JVB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JVB OCA].
==Reference==
==Reference==
Line 36: Line 40:
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Rna-binding]]
[[Category: Rna-binding]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:19:41 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:39:32 2008''

Revision as of 05:39, 29 July 2008

Image:2jvb.png

Template:STRUCTURE 2jvb

Solution Structure of Catalytic Domain of yDcp2

Template:ABSTRACT PUBMED 18280238

About this Structure

2JVB is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

mRNA Decapping Is Promoted by an RNA-Binding Channel in Dcp2., Deshmukh MV, Jones BN, Quang-Dang DU, Flinders J, Floor SN, Kim C, Jemielity J, Kalek M, Darzynkiewicz E, Gross JD, Mol Cell. 2008 Feb 15;29(3):324-36. PMID:18280238

Page seeded by OCA on Tue Jul 29 08:39:32 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jvb"
Personal tools