This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3cgz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_3cgz", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
Line 1: Line 1:
-
[[Image:3cgz.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:3cgz.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3cgz| PDB=3cgz | SCENE= }}
{{STRUCTURE_3cgz| PDB=3cgz | SCENE= }}
-
'''Crystal Structure of Salmonella Sensor Kinase PhoQ catalytic domain'''
+
===Crystal Structure of Salmonella Sensor Kinase PhoQ catalytic domain===
-
==Overview==
+
<!--
-
Sensor kinases in the bacterial two-component system share a unique ATP-binding Bergerat fold with the GHL (gyrase, Hsp90, and MutL) family of proteins. We demonstrated that selected GHL inhibitors bind to the catalytic domain of sensor kinase PhoQ (PhoQcat) using NMR chemical shift perturbation experiments. Using crystallographic approaches, we show that radicicol (an Hsp90 inhibitor) binds and interacts specifically with residues in the ATP-binding pocket of PhoQ. The interaction between radicicol and PhoQcat demonstrates significant similarities as well as differences compared to AMPPNP (a non-hydrolyzable ATP analog) bound to PhoQcat and radicicol bound to Hsp90. Our results suggest that GHL inhibitors may be useful lead compounds for developing sensor kinase inhibitors.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18440021}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18440021 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18440021}}
==About this Structure==
==About this Structure==
Line 42: Line 46:
[[Category: Two-component regulatory system]]
[[Category: Two-component regulatory system]]
[[Category: Virulence]]
[[Category: Virulence]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 14 11:33:29 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:48:25 2008''

Revision as of 05:48, 29 July 2008

Image:3cgz.png

Template:STRUCTURE 3cgz

Crystal Structure of Salmonella Sensor Kinase PhoQ catalytic domain

Template:ABSTRACT PUBMED 18440021

About this Structure

3CGZ is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ., Guarnieri MT, Zhang L, Shen J, Zhao R, J Mol Biol. 2008 May 23;379(1):82-93. Epub 2008 Mar 26. PMID:18440021

Page seeded by OCA on Tue Jul 29 08:48:25 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3cgz"
Personal tools