1sbb

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[[Image:1sbb.gif|left|200px]]
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{{Seed}}
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[[Image:1sbb.png|left|200px]]
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{{STRUCTURE_1sbb| PDB=1sbb | SCENE= }}
{{STRUCTURE_1sbb| PDB=1sbb | SCENE= }}
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'''T-CELL RECEPTOR BETA CHAIN COMPLEXED WITH SUPERANTIGEN SEB'''
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===T-CELL RECEPTOR BETA CHAIN COMPLEXED WITH SUPERANTIGEN SEB===
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==Overview==
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Superantigens (SAGs) are a class of immunostimulatory proteins of bacterial or viral origin that activate T cells by binding to the V beta domain of the T cell antigen receptor (TCR). The three-dimensional structure of the complex between a TCR beta chain (mouse V beta8.2) and the SAG staphylococcal enterotoxin B (SEB) at 2.4 A resolution reveals why SEB recognizes only certain V beta families, as well as why only certain SAGs bind mouse V beta8.2. Models of the TCR-SEB-peptide/MHC class II complex indicate that V alpha interacts with the MHC beta chain in the TCR-SAG-MHC complex. The extent of the interaction is variable and is largely determined by the geometry of V alpha/V beta domain association. This variability can account for the preferential expression of certain V alpha regions among T cells reactive with SEB.
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The line below this paragraph, {{ABSTRACT_PUBMED_9881971}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9881971 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9881971}}
==About this Structure==
==About this Structure==
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[[Category: Superantigen]]
[[Category: Superantigen]]
[[Category: T cell receptor]]
[[Category: T cell receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:30:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:17:39 2008''

Revision as of 06:17, 29 July 2008

Image:1sbb.png

Template:STRUCTURE 1sbb

T-CELL RECEPTOR BETA CHAIN COMPLEXED WITH SUPERANTIGEN SEB

Template:ABSTRACT PUBMED 9881971

About this Structure

1SBB is a Protein complex structure of sequences from Mus musculus and Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the complex between a T cell receptor beta chain and the superantigen staphylococcal enterotoxin B., Li H, Llera A, Tsuchiya D, Leder L, Ysern X, Schlievert PM, Karjalainen K, Mariuzza RA, Immunity. 1998 Dec;9(6):807-16. PMID:9881971

Page seeded by OCA on Tue Jul 29 09:17:39 2008

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