1pzs

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{{STRUCTURE_1pzs| PDB=1pzs | SCENE= }}
{{STRUCTURE_1pzs| PDB=1pzs | SCENE= }}
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'''Crystal Structure of a Cu-Zn Superoxide Dismutase from Mycobacterium tuberculosis at 1.63 resolution'''
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===Crystal Structure of a Cu-Zn Superoxide Dismutase from Mycobacterium tuberculosis at 1.63 resolution===
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==Overview==
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The sodC-encoded Mycobacterium tuberculosis superoxide dismutase (SOD) shows high sequence homology to other members of the copper/zinc-containing SOD family. Its three-dimensional structure is reported here, solved by x-ray crystallography at 1.63-A resolution. Metal analyses of the recombinant protein indicate that the native form of the enzyme lacks the zinc ion, which has a very important structural and functional role in all other known enzymes of this class. The absence of zinc within the active site is due to significant rearrangements in the zinc subloop, including deletion or mutation of the metal ligands His115 and His123. Nonetheless, the enzyme has a catalytic rate close to the diffusion limit; and unlike all other copper/zinc-containing SODs devoid of zinc, the geometry of the copper site is pH-independent. The protein shows a novel dimer interface characterized by a long and rigid loop, which confers structural stability to the enzyme. As the survival of bacterial pathogens within their host critically depends on their ability to recruit zinc in highly competitive environments, we propose that the observed structural rearrangements are required to build up a zinc-independent but fully active and stable copper-containing SOD.
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(as it appears on PubMed at http://www.pubmed.gov), where 15155722 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15155722}}
==About this Structure==
==About this Structure==
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[[Category: Greek key beta barrel]]
[[Category: Greek key beta barrel]]
[[Category: Metal binding]]
[[Category: Metal binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:41:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:32:07 2008''

Revision as of 06:32, 29 July 2008

Image:1pzs.png

Template:STRUCTURE 1pzs

Crystal Structure of a Cu-Zn Superoxide Dismutase from Mycobacterium tuberculosis at 1.63 resolution

Template:ABSTRACT PUBMED 15155722

About this Structure

1PZS is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Unique features of the sodC-encoded superoxide dismutase from Mycobacterium tuberculosis, a fully functional copper-containing enzyme lacking zinc in the active site., Spagnolo L, Toro I, D'Orazio M, O'Neill P, Pedersen JZ, Carugo O, Rotilio G, Battistoni A, Djinovic-Carugo K, J Biol Chem. 2004 Aug 6;279(32):33447-55. Epub 2004 May 23. PMID:15155722

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