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1rxp

From Proteopedia

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[[Image:1rxp.gif|left|200px]]
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{{Seed}}
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[[Image:1rxp.png|left|200px]]
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{{STRUCTURE_1rxp| PDB=1rxp | SCENE= }}
{{STRUCTURE_1rxp| PDB=1rxp | SCENE= }}
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'''STRUCTURE OF TRYPSIN (ORTHORHOMBIC) WITH 1-(4-TERT-BUTYLCARBAMOYL- PIPERAZINE-1-CARBONYL)-3-(3-GUANIDINO-PROPYL)-4-OXO-AZETIDINE-2-CARBOXYLIC ACID'''
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===STRUCTURE OF TRYPSIN (ORTHORHOMBIC) WITH 1-(4-TERT-BUTYLCARBAMOYL- PIPERAZINE-1-CARBONYL)-3-(3-GUANIDINO-PROPYL)-4-OXO-AZETIDINE-2-CARBOXYLIC ACID===
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==Overview==
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A series of nonguanidine N1-activated C4-carboxy azetidinone tryptase inhibitors was prepared by solid-phase methodology to quickly assess the SAR associated with distal functionality on the N1-activating group. From these studies, potent inhibitors with improved specificity were discovered.
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The line below this paragraph, {{ABSTRACT_PUBMED_15081015}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15081015 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15081015}}
==About this Structure==
==About this Structure==
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Tryptase inhibitor]]
[[Category: Tryptase inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:02:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:33:40 2008''

Revision as of 06:33, 29 July 2008

Image:1rxp.png

Template:STRUCTURE 1rxp

STRUCTURE OF TRYPSIN (ORTHORHOMBIC) WITH 1-(4-TERT-BUTYLCARBAMOYL- PIPERAZINE-1-CARBONYL)-3-(3-GUANIDINO-PROPYL)-4-OXO-AZETIDINE-2-CARBOXYLIC ACID

Template:ABSTRACT PUBMED 15081015

About this Structure

1RXP is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors., Sutton JC, Bolton SA, Davis ME, Hartl KS, Jacobson B, Mathur A, Ogletree ML, Slusarchyk WA, Zahler R, Seiler SM, Bisacchi GS, Bioorg Med Chem Lett. 2004 May 3;14(9):2233-9. PMID:15081015

Page seeded by OCA on Tue Jul 29 09:33:40 2008

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