1t94

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{{STRUCTURE_1t94| PDB=1t94 | SCENE= }}
{{STRUCTURE_1t94| PDB=1t94 | SCENE= }}
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'''Crystal structure of the catalytic core of human DNA polymerase kappa'''
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===Crystal structure of the catalytic core of human DNA polymerase kappa===
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==Overview==
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We present the crystal structure of the catalytic core of human DNA polymerase kappa (hPolkappa), the first structure of a human Y-family polymerase. hPolkappa is implicated in the proficient extension of mispaired primer termini on undamaged DNAs, and in the extension step of lesion bypass. The structure reveals a stubby "fingers" subdomain, which despite its small size appears to be tightly restrained with respect to a putative templating base. The structure also reveals a novel "thumb" subdomain that provides a basis for the importance of the N-terminal extension unique to hPolkappa. And, most surprisingly, the structure reveals the polymerase-associated domain (PAD) juxtaposed on the dorsal side of the "palm" subdomain, as opposed to the fingers subdomain. Together, these properties suggest that the hPolkappa active site is constrained at the site of the templating base and incoming nucleotide, but the polymerase is less constrained following translocation of the lesion.
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(as it appears on PubMed at http://www.pubmed.gov), where 15296733 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15296733}}
==About this Structure==
==About this Structure==
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[[Category: Translesion dna synthesis]]
[[Category: Translesion dna synthesis]]
[[Category: Y-family dna polymerase]]
[[Category: Y-family dna polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:41:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:33:57 2008''

Revision as of 06:33, 29 July 2008

Image:1t94.png

Template:STRUCTURE 1t94

Crystal structure of the catalytic core of human DNA polymerase kappa

Template:ABSTRACT PUBMED 15296733

About this Structure

1T94 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic core of human DNA polymerase kappa., Uljon SN, Johnson RE, Edwards TA, Prakash S, Prakash L, Aggarwal AK, Structure. 2004 Aug;12(8):1395-404. PMID:15296733

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