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1n6t

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[[Image:1n6t.jpg|left|200px]]
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{{STRUCTURE_1n6t| PDB=1n6t | SCENE= }}
{{STRUCTURE_1n6t| PDB=1n6t | SCENE= }}
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'''Solution Structure of the Tachykinin Peptide Neurokinin A'''
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===Solution Structure of the Tachykinin Peptide Neurokinin A===
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==Overview==
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The solution structure of NKA, a decapeptide of mammalian origin, has been characterized by CD spectropolarimetry and 2D proton nuclear magnetic resonance (2D 1H-NMR) spectroscopy in both aqueous and membrane mimetic solvents. Unambiguous NMR assignments of protons have been made with the aid of correlation spectroscopy (DQF-COSY and TOCSY) experiments and nuclear Overhauser effect spectroscopy (NOESY and ROESY) experiments. The distance constraints obtained from the NMR data have been utilized to generate a family of structures, which have been refined using restrained energy minimization and dynamics. These data show that in water NKA prefers to be in an extended chain conformation whereas a helical conformation is induced in the central core and the C-terminal region (D4-M10) of the peptide in the presence of perdeuterated dodecylphosphocholine (DPC) micelles, a membrane model system. Though less defined the N-terminus also displays some degree of order and a possible turn structure. The conformation adopted by NKA in the presence of DPC micelles represents a structural motif typical of neurokinin-2 selective agonists and is similar to that reported for eledoisin in hydrophobic environment.
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The line below this paragraph, {{ABSTRACT_PUBMED_14645089}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14645089 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14645089}}
==About this Structure==
==About this Structure==
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1N6T is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6T OCA].
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1N6T is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6T OCA].
==Reference==
==Reference==
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[[Category: Helix]]
[[Category: Helix]]
[[Category: Lipid induced conformation]]
[[Category: Lipid induced conformation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:10:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:47:52 2008''

Revision as of 06:47, 29 July 2008

Image:1n6t.png

Template:STRUCTURE 1n6t

Solution Structure of the Tachykinin Peptide Neurokinin A

Template:ABSTRACT PUBMED 14645089

About this Structure

1N6T is a Single protein structure. Full experimental information is available from OCA.

Reference

Three-dimensional structure of the mammalian tachykinin peptide neurokinin A bound to lipid micelles., Chandrashekar IR, Cowsik SM, Biophys J. 2003 Dec;85(6):4002-11. PMID:14645089

Page seeded by OCA on Tue Jul 29 09:47:52 2008

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