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1vbs

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[[Image:1vbs.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1vbs| PDB=1vbs | SCENE= }}
{{STRUCTURE_1vbs| PDB=1vbs | SCENE= }}
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'''STRUCTURE OF CYCLOPHILIN COMPLEXED WITH (D)ALA CONTAINING TETRAPEPTIDE'''
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===STRUCTURE OF CYCLOPHILIN COMPLEXED WITH (D)ALA CONTAINING TETRAPEPTIDE===
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==Overview==
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The stereospecificity of peptidyl prolyl cis/trans isomerases (PPIases) was studied using tetrapeptide substrate analogs in which one amino acid residue was replaced by the cognate D-amino acid in various positions of the peptide chain. Reversed stereocenters around proline markedly increased the rate of the spontaneous trans to cis isomerization of the prolyl bond whereas cis to trans isomerizations were less sensitive. PPIases like human cyclophilin18, human FKBP12, Escherichia coli parvulin10 and the PPIase domain of E. coli trigger factor exhibited stereoselectivity demanding at the P1 to P2' position of the substrate chain. The discriminating factor for stereoselectivity was the lack of formation of the Michaelis complexes of the diastereomeric substrates. However, D-alanine at the P1 position preserved considerable affinity to the active site, and largely prevented activation of the catalytic machinery for all PPIases investigated.
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The line below this paragraph, {{ABSTRACT_PUBMED_9720925}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9720925 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9720925}}
==About this Structure==
==About this Structure==
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[[Category: Mechanism]]
[[Category: Mechanism]]
[[Category: Peptidyl-prolyl isomerase]]
[[Category: Peptidyl-prolyl isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:20:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:48:39 2008''

Revision as of 06:48, 29 July 2008

Image:1vbs.png

Template:STRUCTURE 1vbs

STRUCTURE OF CYCLOPHILIN COMPLEXED WITH (D)ALA CONTAINING TETRAPEPTIDE

Template:ABSTRACT PUBMED 9720925

About this Structure

1VBS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Mapping the stereospecificity of peptidyl prolyl cis/trans isomerases., Schiene C, Reimer U, Schutkowski M, Fischer G, FEBS Lett. 1998 Aug 7;432(3):202-6. PMID:9720925

Page seeded by OCA on Tue Jul 29 09:48:39 2008

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