1vnc

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[[Image:1vnc.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1vnc| PDB=1vnc | SCENE= }}
{{STRUCTURE_1vnc| PDB=1vnc | SCENE= }}
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'''CHLOROPEROXIDASE FROM THE FUNGUS CURVULARIA INAEQUALIS'''
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===CHLOROPEROXIDASE FROM THE FUNGUS CURVULARIA INAEQUALIS===
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==Overview==
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The chloroperoxidase (EC 1.11.1.-) from the fungus Curvularia inaequalis belongs to a class of vanadium enzymes that oxidize halides in the presence of hydrogen peroxide to the corresponding hypohalous acids. The 2.1 A crystal structure (R = 20%) of an azide chloroperoxidase complex reveals the geometry of the catalytic vanadium center. Azide coordinates directly to the metal center, resulting in a structure with azide, three nonprotein oxygens, and a histidine as ligands. In the native state vanadium will be bound as hydrogen vanadate(V) in a trigonal bipyramidal coordination with the metal coordinated to three oxygens in the equatorial plane, to the OH group at one apical position, and to the epsilon 2 nitrogen of a histidine at the other apical position. The protein fold is mainly alpha-helical with two four-helix bundles as main structural motifs and an overall structure different from other structures. The helices pack together to a compact molecule, which explains the high stability of the protein. An amino acid sequence comparison with vanadium-containing bromoperoxidase from the seaweed Ascophyllum nodosum shows high similarities in the regions of the metal binding site, with all hydrogen vanadate(V) interacting residues conserved except for lysine-353, which is an asparagine.
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(as it appears on PubMed at http://www.pubmed.gov), where 8552646 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8552646}}
==About this Structure==
==About this Structure==
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Vanadium-containing haloperoxidase]]
[[Category: Vanadium-containing haloperoxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:43:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:51:55 2008''

Revision as of 06:51, 29 July 2008

Image:1vnc.png

Template:STRUCTURE 1vnc

CHLOROPEROXIDASE FROM THE FUNGUS CURVULARIA INAEQUALIS

Template:ABSTRACT PUBMED 8552646

About this Structure

1VNC is a Single protein structure of sequence from Curvularia inaequalis. Full crystallographic information is available from OCA.

Reference

X-ray structure of a vanadium-containing enzyme: chloroperoxidase from the fungus Curvularia inaequalis., Messerschmidt A, Wever R, Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):392-6. PMID:8552646

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