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1z3q

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{{STRUCTURE_1z3q| PDB=1z3q | SCENE= }}
{{STRUCTURE_1z3q| PDB=1z3q | SCENE= }}
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'''Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7A'''
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===Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7A===
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==Overview==
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The structure of a thaumatin-like protein from banana (Musa acuminata) fruit, an allergen with antifungal properties, was solved at 1.7-A-resolution, by X-ray crystallography. Though the banana protein exhibits a very similar overall fold as thaumatin it markedly differs from the sweet-tasting protein by the presence of a surface exposed electronegative cleft. Due to the presence of this electronegative cleft, the banana thaumatin-like protein (Ban-TLP) acquires a strong (local) electronegative character that eventually explains the observed antifungal activity. Our structural analysis also revealed the presence of conserved residues of exposed epitopic determinants that are presumably responsible for the allergenic properties of banana fruit towards susceptible individuals, and provided evidence that the Ban-TLP shares some structurally highly conserved IgE-binding epitopes with thaumatin-like proteins from fruits or pollen from other plants. In addition, some overlap was detected between the predicted IgE-binding epitopes of the Ban-TLP and IgE-binding epitopes previously identified in the mountain cedar Jun a 3 TLP aeroallergen. The presence of these common epitopes offers a molecular basis for the cross-reactivity between aeroallergens and fruit allergens.
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(as it appears on PubMed at http://www.pubmed.gov), where 16085352 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16085352}}
==About this Structure==
==About this Structure==
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[[Category: Roussel, A.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:08:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:01:55 2008''

Revision as of 07:01, 29 July 2008

Image:1z3q.png

Template:STRUCTURE 1z3q

Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7A

Template:ABSTRACT PUBMED 16085352

About this Structure

Full crystallographic information is available from OCA.

Reference

Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7-A., Leone P, Menu-Bouaouiche L, Peumans WJ, Payan F, Barre A, Roussel A, Van Damme EJ, Rouge P, Biochimie. 2006 Jan;88(1):45-52. Epub 2005 Aug 8. PMID:16085352

Page seeded by OCA on Tue Jul 29 10:01:55 2008

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