This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2gj7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2gj7.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2gj7.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2gj7| PDB=2gj7 | SCENE= }}
{{STRUCTURE_2gj7| PDB=2gj7 | SCENE= }}
-
'''Crystal Structure of a gE-gI/Fc complex'''
+
===Crystal Structure of a gE-gI/Fc complex===
-
==Overview==
+
<!--
-
Herpes simplex virus type-1 expresses a heterodimeric Fc receptor, gE-gI, on the surfaces of virions and infected cells that binds the Fc region of host immunoglobulin G and is implicated in the cell-to-cell spread of virus. gE-gI binds immunoglobulin G at the basic pH of the cell surface and releases it at the acidic pH of lysosomes, consistent with a role in facilitating the degradation of antiviral antibodies. Here we identify the C-terminal domain of the gE ectodomain (CgE) as the minimal Fc-binding domain and present a 1.78-angstroms CgE structure. A 5-angstroms gE-gI/Fc crystal structure, which was independently verified by a theoretical prediction method, reveals that CgE binds Fc at the C(H)2-C(H)3 interface, the binding site for several mammalian and bacterial Fc-binding proteins. The structure identifies interface histidines that may confer pH-dependent binding and regions of CgE implicated in cell-to-cell spread of virus. The ternary organization of the gE-gI/Fc complex is compatible with antibody bipolar bridging, which can interfere with the antiviral immune response.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16646632}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16646632 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16646632}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Fc receptor]]
[[Category: Fc receptor]]
[[Category: Low resolution]]
[[Category: Low resolution]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:10:02 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:39:10 2008''

Revision as of 07:39, 29 July 2008

Image:2gj7.png

Template:STRUCTURE 2gj7

Crystal Structure of a gE-gI/Fc complex

Template:ABSTRACT PUBMED 16646632

About this Structure

2GJ7 is a Protein complex structure of sequences from Cricetulus griseus, Homo sapiens and Human herpesvirus 1. Full crystallographic information is available from OCA.

Reference

Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging., Sprague ER, Wang C, Baker D, Bjorkman PJ, PLoS Biol. 2006 Jun;4(6):e148. Epub 2006 May 2. PMID:16646632

Page seeded by OCA on Tue Jul 29 10:39:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2gj7"
Personal tools