2hpy

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[[Image:2hpy.gif|left|200px]]
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{{Seed}}
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[[Image:2hpy.png|left|200px]]
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{{STRUCTURE_2hpy| PDB=2hpy | SCENE= }}
{{STRUCTURE_2hpy| PDB=2hpy | SCENE= }}
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'''Crystallographic model of lumirhodopsin'''
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===Crystallographic model of lumirhodopsin===
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==Overview==
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Photoactivation of the visual rhodopsin, a prototypical G protein-coupled receptor (GPCR), involves efficient conversion of the intrinsic inverse-agonist 11-cis-retinal to the all-trans agonist. This event leads to the rearrangement of the heptahelical transmembrane bundle, which is thought to be shared by hundreds of GPCRs. To examine this activation mechanism, we determined the x-ray crystallographic model of the photoreaction intermediate of rhodopsin, lumirhodopsin, which represents the conformational state having the nearly complete all-trans agonist form of the retinal. A difference electron density map clearly indicated that the distorted all-trans-retinal in the precedent intermediate bathorhodopsin relaxes by dislocation of the beta-ionone ring in lumirhodopsin, along with significant peptide displacement in the middle of helix III, including approximately two helical turns. This local movement results in the breaking of the electrostatic interhelical restraints mediated by many of the conserved residues among rhodopsin-like GPCRs, with consequent acquisition of full activity.
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The line below this paragraph, {{ABSTRACT_PUBMED_16908857}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16908857 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16908857}}
==About this Structure==
==About this Structure==
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[[Category: G protein-coupled receptor]]
[[Category: G protein-coupled receptor]]
[[Category: Visual pigment]]
[[Category: Visual pigment]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:33:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:52:36 2008''

Revision as of 07:52, 29 July 2008

Image:2hpy.png

Template:STRUCTURE 2hpy

Crystallographic model of lumirhodopsin

Template:ABSTRACT PUBMED 16908857

About this Structure

2HPY is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Local peptide movement in the photoreaction intermediate of rhodopsin., Nakamichi H, Okada T, Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12729-34. Epub 2006 Aug 14. PMID:16908857

Page seeded by OCA on Tue Jul 29 10:52:36 2008

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