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1t3b

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[[Image:1t3b.gif|left|200px]]
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{{STRUCTURE_1t3b| PDB=1t3b | SCENE= }}
{{STRUCTURE_1t3b| PDB=1t3b | SCENE= }}
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'''X-ray Structure of DsbC from Haemophilus influenzae'''
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===X-ray Structure of DsbC from Haemophilus influenzae===
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==Overview==
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Bacterial DsbC proteins are involved in rearranging or reducing mismatched disulfide bonds folding within the periplasm. The X-ray structure of the enzyme from Haemophilus influenzae has been solved and compared with the known structure of the Escherichia coli protein. The proteins act as V-shaped dimers with a large cleft to accommodate substrate proteins. The dimers are anchored by a small N-terminal domain, but have a flexible linker region which allows the larger C-terminal domain, with its reactive sulfhydryls, to clamp down on substrates. The overall folds are very similar, but the comparison shows a wider range of hinge motions than previously thought. The crystal packing of the H. influenzae protein allows the movement of the N-terminal domain with respect to the C-terminal domain through motions in the flexible hinge, generating high thermal parameters and unusually high anisotropy in the crystallographic data.
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(as it appears on PubMed at http://www.pubmed.gov), where 15333920 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15333920}}
==About this Structure==
==About this Structure==
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[[Category: Redox protein]]
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[[Category: Redox-active center]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:27:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:18:40 2008''

Revision as of 08:18, 29 July 2008

Image:1t3b.png

Template:STRUCTURE 1t3b

X-ray Structure of DsbC from Haemophilus influenzae

Template:ABSTRACT PUBMED 15333920

About this Structure

1T3B is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.

Reference

Structure of DsbC from Haemophilus influenzae., Zhang M, Monzingo AF, Segatori L, Georgiou G, Robertus JD, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1512-8. Epub 2004, Aug 26. PMID:15333920

Page seeded by OCA on Tue Jul 29 11:18:40 2008

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