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2p8q

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[[Image:2p8q.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_2p8q| PDB=2p8q | SCENE= }}
{{STRUCTURE_2p8q| PDB=2p8q | SCENE= }}
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'''Crystal Structure of human Importin beta bound to the Snurportin1 IBB-domain'''
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===Crystal Structure of human Importin beta bound to the Snurportin1 IBB-domain===
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==Overview==
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The nuclear import of uridine-rich ribonucleoproteins (U snRNPs) is mediated by the transport adaptor snurportin 1 (SNP1). Similar to importin alpha, SNP1 uses an N-terminal importin beta binding (sIBB) domain to recruit the receptor importin beta and gain access to the nucleus. In this paper, we demonstrate the sIBB-domain has a bipartite nature, which contains two distinct binding determinants for importin beta. The first determinant spans residues 25-65, and includes the previously identified alphaIBB-region of homology. The second binding determinant encompasses residues 1-24 and resembles region 1011-1035 of the nucleoporin 153 (Nup153). The two binding determinants synergize within the sIBB-domain to confer a low nanomolar binding affinity for importin beta, (Kd ~2nM) in an interaction that, in vitro, is displaced by RanGppNHp. We propose that in vivo the synergy of Nup153 and nuclear RanGTP promotes translocation of U snRNPs into the nucleus.
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The line below this paragraph, {{ABSTRACT_PUBMED_18187419}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18187419 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18187419}}
==About this Structure==
==About this Structure==
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[[Category: Protein transport]]
[[Category: Protein transport]]
[[Category: Snurportin]]
[[Category: Snurportin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:36:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:36:36 2008''

Revision as of 08:36, 29 July 2008

Image:2p8q.png

Template:STRUCTURE 2p8q

Crystal Structure of human Importin beta bound to the Snurportin1 IBB-domain

Template:ABSTRACT PUBMED 18187419

About this Structure

2P8Q is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular basis for the recognition of snurportin 1 by importin beta., Mitrousis G, Olia AS, Walker-Kopp N, Cingolani G, J Biol Chem. 2008 Jan 9;. PMID:18187419

Page seeded by OCA on Tue Jul 29 11:36:36 2008

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