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2d0p

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[[Image:2d0p.gif|left|200px]]
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{{Seed}}
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[[Image:2d0p.png|left|200px]]
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{{STRUCTURE_2d0p| PDB=2d0p | SCENE= }}
{{STRUCTURE_2d0p| PDB=2d0p | SCENE= }}
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'''Strcuture of diol dehydratase-reactivating factor in nucleotide free form'''
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===Strcuture of diol dehydratase-reactivating factor in nucleotide free form===
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==Overview==
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The crystal structures of ADP bound and nucleotide-free forms of molecular chaperone-like diol dehydratase-reactivating factor (DDR) were determined at 2.0 and 3.0 A, respectively. DDR exists as a dimer of heterodimer (alphabeta)2. The alpha subunit has four domains: ATPase domain, swiveling domain, linker domain, and insert domain. The beta subunit, composed of a single domain, has a similar fold to the beta subunit of diol dehydratase (DD). The binding of an ADP molecule to the nucleotide binding site of DDR causes a marked conformational change of the ATPase domain of the alpha subunit, which would weaken the interactions between the DDR alpha and beta subunits and make the displacement of the DDR beta subunit by DD through the beta subunit possible. The binding of the DD beta subunit to the DDR alpha subunit induces steric repulsion between the DDR alpha and DD alpha subunits that would lead to the release of a damaged cofactor from inactivated holoDD.
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The line below this paragraph, {{ABSTRACT_PUBMED_16338403}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16338403 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16338403}}
==About this Structure==
==About this Structure==
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[[Category: Yamanishi, M.]]
[[Category: Yamanishi, M.]]
[[Category: Chaperone]]
[[Category: Chaperone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:28:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:41:48 2008''

Revision as of 08:41, 29 July 2008

Image:2d0p.png

Template:STRUCTURE 2d0p

Strcuture of diol dehydratase-reactivating factor in nucleotide free form

Template:ABSTRACT PUBMED 16338403

About this Structure

2D0P is a Protein complex structure of sequences from Klebsiella oxytoca. Full crystallographic information is available from OCA.

Reference

Release of a damaged cofactor from a coenzyme B12-dependent enzyme: X-ray structures of diol dehydratase-reactivating factor., Shibata N, Mori K, Hieda N, Higuchi Y, Yamanishi M, Toraya T, Structure. 2005 Dec;13(12):1745-54. PMID:16338403

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