1nfi

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[[Image:1nfi.gif|left|200px]]
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{{Seed}}
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[[Image:1nfi.png|left|200px]]
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{{STRUCTURE_1nfi| PDB=1nfi | SCENE= }}
{{STRUCTURE_1nfi| PDB=1nfi | SCENE= }}
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'''I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX'''
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===I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX===
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==Overview==
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The inhibitory protein, IkappaBalpha, sequesters the transcription factor, NF-kappaB, as an inactive complex in the cytoplasm. The structure of the IkappaBalpha ankyrin repeat domain, bound to a partially truncated NF-kappaB heterodimer (p50/ p65), has been determined by X-ray crystallography at 2.7 A resolution. It shows a stack of six IkappaBalpha ankyrin repeats facing the C-terminal domains of the NF-kappaB Rel homology regions. Contacts occur in discontinuous patches, suggesting a combinatorial quality for ankyrin repeat specificity. The first two repeats cover an alpha helically ordered segment containing the p65 nuclear localization signal. The position of the sixth ankyrin repeat shows that full-length IkappaBalpha will occlude the NF-kappaB DNA-binding cleft. The orientation of IkappaBalpha in the complex places its N- and C-terminal regions in appropriate locations for their known regulatory functions.
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The line below this paragraph, {{ABSTRACT_PUBMED_9865693}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9865693 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9865693}}
==About this Structure==
==About this Structure==
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[[Category: Jacobs, M D.]]
[[Category: Jacobs, M D.]]
[[Category: Ankyrin repeat]]
[[Category: Ankyrin repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:28:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:51:25 2008''

Revision as of 08:51, 29 July 2008

Image:1nfi.png

Template:STRUCTURE 1nfi

I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX

Template:ABSTRACT PUBMED 9865693

About this Structure

1NFI is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of an IkappaBalpha/NF-kappaB complex., Jacobs MD, Harrison SC, Cell. 1998 Dec 11;95(6):749-58. PMID:9865693

Page seeded by OCA on Tue Jul 29 11:51:25 2008

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