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1udx

From Proteopedia

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{{STRUCTURE_1udx| PDB=1udx | SCENE= }}
{{STRUCTURE_1udx| PDB=1udx | SCENE= }}
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'''Crystal structure of the conserved protein TT1381 from Thermus thermophilus HB8'''
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===Crystal structure of the conserved protein TT1381 from Thermus thermophilus HB8===
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==Overview==
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Obg comprises a unique family of high-molecular mass GTPases conserved from bacteria to eukaryotes. Bacterial Obg is essential for cellular growth, sporulation, and differentiation. Here, we report the crystal structure of the full-length form of Obg from Thermus thermophilus HB8 at 2.07 A resolution, in the nucleotide-free state. It reveals a three-domain arrangement, composed of the N-terminal domain, the guanine nucleotide-binding domain (G domain), and the C-terminal domain. The N-terminal and G domains have the Obg fold and the Ras-like fold, respectively. These global folds are similar to those of the recently published structure of the C-terminal domain-truncated form of Obg from Bacillus subtilis. On the other hand, the C-terminal domain of Obg was found to have a novel fold (the OCT fold). A comparison of the T.thermophilus and B.subtilis nucleotide-free Obg structures revealed significant conformational changes in the switch-I and switch-II regions of the G domain. Notably, the N-terminal domain is rotated drastically, by almost 180 degrees, around the G domain axis. In the T.thermophilus Obg crystal, the nucleotide-binding site of the G domain interacts with the C-terminal domain of the adjacent molecule. These data suggest a possible domain rearrangement of Obg, and a potential role of the C-terminal domain in the regulation of the nucleotide-binding state.
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{{ABSTRACT_PUBMED_15019792}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Tgs domain]]
[[Category: Tgs domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:05:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:51:44 2008''

Revision as of 08:51, 29 July 2008

Image:1udx.png

Template:STRUCTURE 1udx

Crystal structure of the conserved protein TT1381 from Thermus thermophilus HB8

Template:ABSTRACT PUBMED 15019792

About this Structure

1UDX is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the GTP-binding protein Obg from Thermus thermophilus HB8., Kukimoto-Niino M, Murayama K, Inoue M, Terada T, Tame JR, Kuramitsu S, Shirouzu M, Yokoyama S, J Mol Biol. 2004 Mar 26;337(3):761-70. PMID:15019792

Page seeded by OCA on Tue Jul 29 11:51:44 2008

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